中国4个民族HLA等位基因和单倍型的不同分布。

Tissue antigens Pub Date : 2012-11-01 DOI:10.1111/tan.12007
Y Yao, L Shi, Y Tao, J K Kulski, K Lin, X Huang, H Xiang, J Chu, L Shi
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引用次数: 24

摘要

人类白细胞抗原(HLA)等位基因和单倍型在中国北部和南部汉族人群中有明显的分布。然而,许多HLA等位基因和单倍型在中国不同民族的区域分布有限。因此,研究中国南北民族HLA等位基因和单倍型分布的差异是必要和有意义的。采用聚合酶链反应- luminex分型方法,对来自傈僳族、努族、土族和裕固族人群的428例无亲缘关系个体进行HLA-A、-B、-C和-DRB1等位基因分型。计算HLA等位基因的频率和统计推断的单倍型。共有29个HLA-A等位基因、54个HLA-B等位基因、27个HLA-C等位基因和41个HLA-DRB1等位基因分布在这4个群体中,具有不同的等位基因和推断出的群体间单倍型频率。一些等位基因和推断的单倍型在北方(土族和裕固族)和南方(傈僳族和怒族)之间的分布有显著差异。采用系统发育树和主成分分析比较了我们的数据集与其他19个东亚和东南亚人群的HLA多态性。分析表明,傈僳族和怒族属于南方少数民族,而土族和裕固族与北方其他少数民族关系最为密切。因此,通过分析南方傈僳族、女族与北方土族、裕固族的HLA等位基因多态性,揭示了不同民族的人群历史。该结果将有助于未来传染病的关联研究,并有助于更有效地寻找器官/组织移植匹配。
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Distinct HLA allele and haplotype distributions in four ethnic groups of China.

Distinct human leukocyte antigen (HLA) allele and haplotype distributions occur in the northern and southern Han populations of China. However, different ethnic groups in China show limited regional distributions for many HLA alleles and haplotypes. Therefore, it is necessary and meaningful to study the differences in HLA allele and haplotype distribution for northern and southern ethnic groups of China. A total of 428 unrelated individuals from the Lisu, Nu, Tu and Yugur ethnic populations were genotyped for HLA-A, -B, -C and -DRB1 alleles using the PCR-Luminex typing method. The frequencies of HLA alleles and statistically inferred haplotypes were calculated. A total of 29 HLA-A, 54 HLA-B, 27 HLA-C and 41 HLA-DRB1 alleles were spread throughout these four populations with distinct allele and deduced haplotype frequencies between populations. Some alleles and deduced haplotypes exhibited significantly different distributions between northern (Tu and Yugur) and southern groups (Lisu and Nu). A phylogenetic tree and principal component analysis were used to compare the HLA polymorphism between our dataset and 19 other eastern and southeastern Asian populations. This analysis showed that Lisu and Nu belong to a cluster of southern ethnic groups, while Tu and Yugur are most closely related to other northern groups. Thus, distinct ethnic population histories were revealed by analyzing HLA allelic polymorphisms with the HLA profiles of the Lisu and Nu southern Chinese ethnic groups clearly different from the Tu and Yugur northern ethnic groups. The results will be useful for future association studies of infectious disease and contribute toward a more efficient search of organ/tissue matches for transplantation.

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Tissue antigens
Tissue antigens 医学-病理学
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期刊最新文献
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