纳米颗粒结合的动物毒液毒素及其可能的治疗潜力。

Journal of Venom Research Pub Date : 2012-01-01 Epub Date: 2012-10-23
Archita Biswas, Aparna Gomes, Jayeeta Sengupta, Poulami Datta, Santiswarup Singha, Anjan Kr Dasgupta, Antony Gomes
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引用次数: 0

摘要

开发药物的纳米医学方法引起了不同领域的广泛关注,以设计纳米颗粒共轭物,提高潜在生物分子的功效。具有潜在药用价值的动物源毒液毒素是这类药物中很有希望的一类。传统医学体系和民间传说都提到使用毒液毒素治疗各种疾病。研究已经从科学上验证了毒液毒素的药用价值,许多从毒液毒素中提取的活性成分已经用于临床或正在进行临床试验。纳米医学是一个新兴的医学领域,利用纳米技术开发纳米级分子,使这些分子更容易被细胞吸收并发挥更好的疗效,而大分子则容易被清除。本综述将重点介绍一些潜在的毒液和毒素,以及蛇、两栖动物、蝎子和蜜蜂等的纳米颗粒共轭毒液-毒素,为治疗新出现的疾病提供可能的线索。
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Nanoparticle-conjugated animal venom-toxins and their possible therapeutic potential.

Nano-medical approaches to develop drugs have attracted much attention in different arenas to design nanoparticle conjugates for better efficacy of the potential bio-molecules. A group of promising candidates of this category would be venom-toxins of animal origin of potential medicinal value. Traditional systems of medicine as well as folklores mention the use of venom-toxins for the treatment of various diseases. Research has led to scientific validation of medicinal applications of venoms-toxins and many active constituents derived from venoms-toxins are already in clinical use or under clinical trial. Nanomedicine is an emerging field of medicine where nanotechnology is used to develop molecules of nano-scale dimension, so that these molecules can be taken up by the cells more easily and have better efficacy, as compared to large molecules that may tend to get eliminated. This review will focus on some of the potential venoms and toxins along with nanoparticle conjugated venom-toxins of snakes, amphibians, scorpions and bees, etc., for possible therapeutic clues against emerging diseases.

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