血浆纤溶酶原激活物抑制剂-1与中国北方汉族人群终末期增殖性糖尿病视网膜病变相关

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-10-14 DOI:10.1155/2012/350852
Ze-long Zhong, Song Chen
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引用次数: 18

摘要

目的:探讨中国北方汉族2型糖尿病(T2DM)患者终末期增殖性糖尿病视网膜病变(PDR)的预测因素。方法:我们研究了153例连续糖尿病终末期PDR患者(男性62例,女性91例)、123例连续无终末期PDR患者(男性48例,女性75例)和151例正常受试者(男性63例,女性88例)的特征。本研究仅包括每位患者或健康受试者的一只眼睛。建立单因素logistic回归模型和多因素logistic回归模型评价终末期PDR的预测因素。结果:在单因素分析中,收缩压、舒张压、糖尿病病程、T2DM家族史和纤溶酶原激活物抑制剂-1 (PAI-1)与终末期PDR显著相关。多因素分析后,T2DM家族史、血浆PAI-1水平、吸烟和糖尿病病程是与终末期PDR相关的四个阳性预测因素。结论:中国北方汉族T2DM患者血浆PAI-1水平升高与终末期PDR相关。
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Plasma plasminogen activator inhibitor-1 is associated with end-stage proliferative diabetic retinopathy in the Northern Chinese Han population.

Objective: To identify predictors of end-stage proliferative diabetic retinopathy (PDR) in a cohort of individuals with type 2 diabetes mellitus (T2DM) from the Northern Chinese Han population.

Methods: We investigated characteristics of 153 consecutive diabetic patients with end-stage PDR (62 males, 91 females), 123 consecutive PDR patients without end-stage PDR (48 males, 75 females), and 151 normal subjects (63 males, 88 females). Only one eye of each patient or healthy subject was included in this study. Univariate logistic regression models and multivariate logistic regression models were constructed to evaluate the predictors of end-stage PDR.

Results: In univariate analysis, systolic blood pressure, diastolic blood pressure, duration of diabetes, family history of T2DM, and plasminogen activator inhibitor-1 (PAI-1) were significently associated with end-stage PDR. After multivariate analysis, family history of T2DM, plasma PAI-1 levels, smoking, and duration of diabetes were four positive predictors associated with end-stage PDR.

Conclusions: Higher plasma levels of PAI-1 were associated with end-stage PDR in the Northern Chinese Han population with T2DM.

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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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