【维曼在HIV/AIDS患者中的作用】。

Q4 Medicine Revista Cubana de Medicina Tropical Pub Date : 2010-09-01
Lizette Gil del Valle, Teresita Serrano López, Odalys Calderón Fuentes, Felicita Núñez Sánchez, Rolando D Tápanes Peraza, Jorge Pérez Avila
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引用次数: 0

摘要

氧化应激(OS)已被认为是HIV感染演变为艾滋病的一个辅助因素。目的:评价维曼可能的抗氧化作用和对人体几个系统功能的影响,从而导致使用维曼的毒理学安全性。方法:68例hiv血清阳性患者随机分为两组;第一组在六个月内服用Vimang,另一组服用安慰剂。测定大鼠的氧化还原条件和血液学、肾功能、肝功能生化指标。此外,在研究开始和结束的7天内,通过调查来评估饮食摄入量。结果:Vimang组与安慰剂组相比,两组之间氧化还原数据的阳性变化有统计学意义。研究结束时,两组膳食摄入评价指标及肾功能、血液学、肝功能生化指标均无显著差异。结论:在对HIV/AIDS患者进行的为期6个月的研究中,Vimang显示出抗氧化作用,无任何毒性影响。
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[Effect of Vimang in HIV/AIDS patients].

Introduction: the oxidative stress (OS) has been recognized as a co-factor of HIV infection evolution to AIDS condition.

Objectives: to evaluate the possible antioxidant effect and the impact on the functioning of several systems in the body, resulting in the toxicological safety of Vimang use.

Methods: sixty eight HIV-seropositive patients were double-blind randomized in two groups; the first was supplied with Vimang during six months and the other with placebo. Redox condition and the biochemical indexes of the hematological, renal and hepatic functions were measured. Also, dietary intake was assessed through surveys administered for 7 days at the beginning and at the end of the study.

Results: there were statistically significant differences between the groups regarding positive change in redox figures in Vimang group compared to those of the placebo group. No significant difference was found either in the evaluated dietary intake indexes or in the biochemical indexes of the renal, hematological and hepatic functions at the end of the study.

Conclusions: Vimang antioxidant effect was shown, without any toxic influence during the six month-study conducted in HIV/AIDS patients.

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来源期刊
Revista Cubana de Medicina Tropical
Revista Cubana de Medicina Tropical Medicine-Infectious Diseases
CiteScore
0.30
自引率
0.00%
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0
期刊介绍: La Revista Cubana de Medicina Tropical tiene la misión de publicar artículos científicos especializados en medicina tropical, microbiología, parasitología, epidemiología y otras especialidades afines. Se distribuye directamente por el editor a los suscriptores en formato impreso (ISSN 0375-0760). Está dirigida a profesionales y técnicos en el campo de la medicina tropical, microbiología, parasitología y epidemiología. Recibe contribuciones en idioma español, inglés y portugués sin distinción en el país de procedencia.
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