灌注生物反应器在骨组织工程中的作用。

Biomatter Pub Date : 2012-10-01 DOI:10.4161/biom.22170
Diana Alves Gaspar, Viviane Gomide, Fernando Jorge Monteiro
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引用次数: 0

摘要

组织工程学已成为目前治疗骨骼损伤和缺损的一种可能的替代方法。然而,普通的组织工程方法在开发功能性组织方面存在一些障碍,如营养和代谢物运输不足以及细胞分布不均匀。在生物反应器系统中以三维结构培养骨细胞是解决这些问题的一种方法,因为它能改善培养系统中的质量运输。针对骨组织工程的旋转瓶、旋转壁容器和灌注系统已得到研究,在此基础上,还研究了支持细胞播种和机械刺激的变体。本综述旨在概述骨组织工程生物反应器系统的概念、优势和未来应用,重点介绍不同灌注系统的设计和可优化的参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The role of perfusion bioreactors in bone tissue engineering.

Tissue engineering has emerged as a possible alternative to current treatments for bone injuries and defects. However, the common tissue engineering approach presents some obstacles to the development of functional tissues, such as insufficient nutrient and metabolite transport and non-homogenous cell distribution. Culture of bone cells in three-dimensional constructs in bioreactor systems is a solution for those problems as it improves mass transport in the culture system. For bone tissue engineering spinner flasks, rotating wall vessels and perfusion systems have been investigated, and based on these, variations that support cell seeding and mechanical stimulation have also been researched. This review aims at providing an overview of the concepts, advantages and future applications of bioreactor systems for bone tissue engineering with emphasis on the design of different perfusion systems and parameters that can be optimized.

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