Muthusamy Kunnimalaiyaan, Megan R Haymart, Herbert Chen
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Tumor suppressor role of notch1 and raf-1 signaling in medullary thyroid cancer cells.
There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
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