HMGB1:前列腺癌的一个有前景的治疗靶点

IF 2.3 Q3 ONCOLOGY Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-05-12 DOI:10.1155/2013/157103

Munirathinam Gnanasekar, Ramaswamy Kalyanasundaram, Guoxing Zheng, Aoshuang Chen, Maarten C Bosland, André Kajdacsy-Balla

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引用次数: 43

摘要

高迁移率组框1 (HMGB1)是几十年前发现的一种染色质结合蛋白。现在越来越明显的是，HMGB1在动脉粥样硬化、糖尿病、关节炎、败血症和癌症等几种疾病中起着重要作用。令人感兴趣的是，HMGB1的失调如何导致无数的疾病状况。有趣的是，HMGB1参与了癌症进展过程中的细胞增殖、血管生成和转移。此外，HMGB1已被证明发挥细胞内和细胞外功能，激活关键的致癌信号通路。本文重点介绍了HMGB1在前列腺癌发生发展中的作用，并强调了HMGB1作为前列腺癌治疗关键靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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HMGB1: A Promising Therapeutic Target for Prostate Cancer.

High mobility group box 1 (HMGB1) was originally discovered as a chromatin-binding protein several decades ago. It is now increasingly evident that HMGB1 plays a major role in several disease conditions such as atherosclerosis, diabetes, arthritis, sepsis, and cancer. It is intriguing how deregulation of HMGB1 can result in a myriad of disease conditions. Interestingly, HMGB1 is involved in cell proliferation, angiogenesis, and metastasis during cancer progression. Furthermore, HMGB1 has been demonstrated to exert intracellular and extracellular functions, activating key oncogenic signaling pathways. This paper focuses on the role of HMGB1 in prostate cancer development and highlights the potential of HMGB1 to serve as a key target for prostate cancer treatment.

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来源期刊

Prostate Cancer ONCOLOGY-

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.