治疗饮食失调症的药物选择。

ISRN Pharmacology Pub Date : 2013-07-15 eCollection Date: 2013-01-01 DOI:10.1155/2013/352865
W Milano, M De Rosa, L Milano, A Riccio, B Sanseverino, A Capasso
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引用次数: 0

摘要

饮食失调症(DCA)是一种复杂的系统性疾病,对社会的影响很大,而且往往是慢性病,伴有严重的医疗和精神并发症。文献数据显示,有充分的证据表明,使用 SSRIs(特别是大剂量氟西汀)治疗 BN 既能减少 BED 患者的暴食危机,又能在短期内减少暴食发作。此外,托吡酯(一种 AED)在降低体重的同时减少狂欢发作的频率和程度方面也显示出良好的效果,这两种药物都适用于 BN 即 BED 的治疗。迄今为止,适量的数据支持使用低剂量的第二代抗精神病药物来减少体重和体形的两极分化、强迫成分和 AN 患者的焦虑。有关饮食失调症长期药物治疗的文献数据仍然非常有限。但必须记住的是,药物疗法在治疗与进食障碍并发的精神疾病(如情绪障碍、焦虑、失眠、强迫性人格障碍和行为)方面具有显著疗效。
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The pharmacological options in the treatment of eating disorders.

The eating disorders (DCA) are complex systemic diseases with high social impact, which tend to become chronic with significant medical and psychiatric comorbidities. The literature data showed that there is good evidence to suggest the use of SSRIs, particularly at high doses of fluoxetine, in the treatment of BN reducing both the crisis of binge that the phenomena compensates and reducing the episodes of binge in patients with BED in the short term. Also, the topiramate (an AED) showed a good effectiveness in reducing the frequency and magnitude of episodes of binge with body weight reduction, both in the BN that is in the therapy of BED. To date, modest data support the use of low doses of second-generation antipsychotics in an attempt to reduce the creation of polarized weight and body shapes, the obsessive component, and anxiety in patients with AN. Data in the literature on long-term drug treatment of eating disorders are still very modest. It is essential to remember that the pharmacotherapy has, however, a remarkable efficacy in treating psychiatric disorders that occur in comorbidity with eating disorders, such as mood disorders, anxiety, insomnia, and obsessive-compulsive personality disorders and behavior.

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