精神分裂症大麻滥用患者心理旋转能力的神经相关性:一项FMRI研究。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2013-01-01 Epub Date: 2013-07-17 DOI:10.1155/2013/543842
Stéphane Potvin, Josiane Bourque, Myriam Durand, Olivier Lipp, Pierre Lalonde, Emmanuel Stip, Sylvain Grignon, Adrianna Mendrek
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引用次数: 14

摘要

越来越多的证据表明,大麻滥用/依赖与精神分裂症患者更好的认知有矛盾的联系。因此,我们对14名大麻滥用精神分裂症患者(DD)、14名非大麻滥用精神分裂症患者(SCZ)和21名健康对照(hc)的视觉空间能力进行了功能磁共振成像(fMRI)研究。参与者在接受扫描时进行了一项心理旋转任务。精神分裂症组与精神分裂症组之间的错误数无显著差异,两组在心理旋转任务上的错误均多于精神分裂症组。与HC相比,SCZ患者左侧丘脑的激活增加,而DD患者右侧边缘上回的激活增加。在这两种情况下,过度激活可能反映了代偿性努力。此外,与HC和DD患者相比,SCZ患者左侧顶叶上回的激活减少。后一个结果初步表明,相对于SCZ患者,DD患者视觉空间能力的神经生理过程部分保留,这与精神分裂症患者大麻滥用与更好的认知功能相关的研究结果一致。需要进一步的功能磁共振成像研究来检查伴有或不伴有大麻使用障碍的精神分裂症患者的其他认知功能障碍的神经相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The neural correlates of mental rotation abilities in cannabis-abusing patients with schizophrenia: an FMRI study.

Growing evidence suggests that cannabis abuse/dependence is paradoxically associated with better cognition in schizophrenia. Accordingly, we performed a functional magnetic resonance imaging (fMRI) study of visuospatial abilities in 14 schizophrenia patients with cannabis abuse (DD), 14 nonabusing schizophrenia patients (SCZ), and 21 healthy controls (HCs). Participants performed a mental rotation task while being scanned. There were no significant differences in the number of mistakes between schizophrenia groups, and both made more mistakes on the mental rotation task than HC. Relative to HC, SCZ had increased activations in the left thalamus, while DD patients had increased activations in the right supramarginal gyrus. In both cases, hyper-activations are likely to reflect compensatory efforts. In addition, SCZ patients had decreased activations in the left superior parietal gyrus compared to both HC and DD patients. This latter result tentatively suggests that the neurophysiologic processes underlying visuospatial abilities are partially preserved in DD, relative to SCZ patients, consistently with the findings showing that cannabis abuse in schizophrenia is associated with better cognitive functioning. Further fMRI studies are required to examine the neural correlates of other cognitive dysfunctions in schizophrenia patients with and without comorbid cannabis use disorder.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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