骨靶向治疗转移性去势抵抗性前列腺癌:不断发展的范式。

IF 2.3 Q3 ONCOLOGY Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-08-28 DOI:10.1155/2013/210686
Joelle El-Amm, Ashley Freeman, Nihar Patel, Jeanny B Aragon-Ching
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引用次数: 40

摘要

大多数转移性去势抵抗性前列腺癌(mCRPC)患者发生骨转移,由于骨骼相关事件(SREs)导致显著的发病率和死亡率。为了预防SREs,有几种骨靶向药物正在临床使用或开发中。双膦酸盐是第一类研究用于预防SREs的药物,唑来膦酸是fda批准用于该适应症的唯一双膦酸盐。另一种骨靶向药物是denosumab,它是一种完全人源化的单克隆抗体,与RANK-L结合,从而抑制RANK-L介导的骨吸收。虽然包括锶和钐在内的几种放射性药物已被批准用于缓解mCRPC患者的疼痛,但alpharadin是第一个显示出显着总体生存益处的放射性药物。包括恩杂鲁胺和阿比特龙在内的当代治疗选择对疼痛缓解和SREs也有影响。其他新的骨靶向药物目前正在开发中,包括受体酪氨酸激酶抑制剂卡博赞替尼和达沙替尼。mCRPC的新兴治疗方法在预防骨转移并发症的最重要来源之一方面取得了巨大进展。
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Bone-targeted therapies in metastatic castration-resistant prostate cancer: evolving paradigms.

Majority of patients with metastatic castrate resistant prostate cancer (mCRPC) develop bone metastases which results in significant morbidity and mortality as a result of skeletal-related events (SREs). Several bone-targeted agents are either in clinical use or in development for prevention of SREs. Bisphosphonates were the first class of drugs investigated for prevention of SREs and zoledronic acid is the only bisphosphonate that is FDA-approved for this indication. Another bone-targeted agent is denosumab which is a fully humanized monoclonal antibody that binds to the RANK-L thereby inhibiting RANK-L mediated bone resorption. While several radiopharmaceuticals were approved for pain palliation in mCRPC including strontium and samarium, alpharadin is the first radiopharmaceutical to show significant overall survival benefit. Contemporary therapeutic options including enzalutamide and abiraterone have effects on pain palliation and SREs as well. Other novel bone-targeted agents are currently in development, including the receptor tyrosine kinase inhibitors cabozantinib and dasatinib. Emerging therapeutics in mCRPC has resulted in great strides in preventing one of the most significant sources of complications of bone metastases.

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来源期刊
Prostate Cancer
Prostate Cancer ONCOLOGY-
CiteScore
2.70
自引率
0.00%
发文量
9
审稿时长
13 weeks
期刊介绍: Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
期刊最新文献
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