两种PANSS五因素模型在精神分裂症患者临床项目中评估社会心理结果的效用。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2013-01-01 Epub Date: 2013-12-05 DOI:10.1155/2013/705631
Jeanette M Jerrell, Stephanie Hrisko
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引用次数: 20

摘要

使用来自阳性和阴性综合征量表(PANSS)两种模型的症状因素作为协变量,根据随机对照试验评估抗精神病药物对108名精神分裂症患者的有效性,比较了消费者心理社会功能、药物依从性/依从性和治疗满意度结果随时间的变化。使用随机效应回归分析来确定这两个5因素模型作为协变量在估计随时间变化和回归方程对每个结果的拟合优度方面的相对性能。自我报告的社会心理功能与阳性和阴性综合征的缓解显著相关,而患者满意度与兴奋/激活症状的控制更为密切和显著相关。访谈者评价的社会心理功能与阳性和阴性症状的缓解以及兴奋/激活和定向障碍/自闭症症状显著相关。PANSS的VDG 5因素模型代表了评估与改善的社会心理结局和功能恢复相关的症状相关变化的最佳“拟合优度”模型。使用PANSS评估的精神分裂症综合征的五因素模型在确定心理社会和满意度随时间变化的预测因子方面具有不同的价值,但在改善药物依从性/依从性方面则没有价值。
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Utility of Two PANSS 5-Factor Models for Assessing Psychosocial Outcomes in Clinical Programs for Persons with Schizophrenia.

Using symptom factors derived from two models of the Positive and Negative Syndrome Scale (PANSS) as covariates, change over time in consumer psychosocial functioning, medication adherence/compliance, and treatment satisfaction outcomes are compared based on a randomized, controlled trial assessing the effectiveness of antipsychotic medications for 108 individuals diagnosed with schizophrenia. Random effects regression analysis was used to determine the relative performance of these two 5-factor models as covariates in estimating change over time and the goodness of fit of the regression equations for each outcome. Self-reported psychosocial functioning was significantly associated with the relief of positive and negative syndromes, whereas patient satisfaction was more closely and significantly associated with control of excited/activation symptoms. Interviewer-rated psychosocial functioning was significantly associated with relief of positive and negative symptoms, as well as excited/activation and disoriented/autistic preoccupation symptoms. The VDG 5-factor model of the PANSS represents the best "goodness of fit" model for assessing symptom-related change associated with improved psychosocial outcomes and functional recovery. Five-factor models of the syndromes of schizophrenia, as assessed using the PANSS, are differentially valuable in determining the predictors of psychosocial and satisfaction changes over time, but not of improved medication adherence/compliance.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
期刊最新文献
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