第二代抗精神病药物治疗急性精神病患者QTc延长的研究。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2013-01-01 Epub Date: 2013-12-31 DOI:10.1155/2013/375020
Erik Johnsen, Kristina Aanesen, Sanjeevan Sriskandarajah, Rune A Kroken, Else-Marie Løberg, Hugo A Jørgensen
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引用次数: 8

摘要

QTc间期延长是几种抗精神病药物的副作用,与点扭转性心律失常和心源性猝死的风险相关。关于是否应该对开始服用抗精神病药物的患者强制进行心电图(ECG)评估的争论正在进行。为了研究QTc延长在临床相关患者组中的作用,我们连续招募了171名急诊科住院的成年精神病患者。在基线时、出院时或最迟在6周后(出院/6周)记录心电图,从而反映急性期治疗期。基线时平均QTc间隔为421.1 (30.4)ms, QTc间隔与躁动评分呈正相关,而QTc间隔与血清钙水平呈负相关。共有11.6%的患者QTc间隔异常延长,另有14.3%的患者QTc间隔有边缘性延长。出院/6周时,相应比例分别降至4.2%和5.3%。QTc时间间隔延长对比例的降低有统计学意义(卡方精确检验:P = 0.046)。发现大约四分之一的患者有临界或延长的QTc间隔,这可能表明在这一人群中必须进行心电图记录。该试验已在ClinicalTrials.gov注册,ID: NCT00932529。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics.

QTc interval prolongation is a side effect of several antipsychotic drugs, with associated risks of torsade de pointes arrhythmias and sudden cardiac death. There is an ongoing debate of whether or not electrocardiogram (ECG) assessments should be mandatory in patients starting antipsychotic drugs. To investigate QTc prolongation in a clinically relevant patient group 171 adult patients acutely admitted to an emergency ward for psychosis were consecutively recruited. ECGs were recorded at baseline and then at discharge or after 6 weeks at the latest (discharge/6 weeks), thus reflecting the acute phase treatment period. The mean QTc interval was 421.1 (30.4) ms at baseline and there was a positive association between the QTc interval and the agitation score whereas the QTc interval was inversely associated with the serum calcium level. A total of 11.6% had abnormally prolonged QTc intervals and another 14.3% had borderline prolongation. At discharge/6 weeks, the corresponding proportions were reduced to 4.2% and 5.3%, respectively. The reduction of the proportion with prolonged QTc intervals reached statistical significance (chi-square exact test: P = 0.046). The finding of about one-quarter of the patients with borderline or prolonged QTc intervals could indicate mandatory ECG recordings in this population. This trial is registered with ClinicalTrials.gov ID: NCT00932529.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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