特发性葡萄膜炎与家族性地中海热:有关系吗?

IF 1.7 Q4 IMMUNOLOGY Autoimmune Diseases Pub Date : 2014-01-01 Epub Date: 2014-01-30 DOI:10.1155/2014/238931
Farhad Salehzadeh, Ozra Yasrebi, Mahsa Hosseini Khotbesara, Maryam Hosseini Khotbesara
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引用次数: 9

摘要

介绍。家族性地中海热(FMF)是一种以发热和多浆液炎发作为特征的自身炎症性疾病。FMF通常与其他自身免疫性疾病相关,如类风湿关节炎、结节性多动脉炎(PAN)和Behcet。葡萄膜炎是一种由潜在的感染性和炎症性疾病引起的炎症过程。本研究探讨特发性葡萄膜炎与FMF之间的可能关系。方法。对特发性葡萄膜炎患者进行12个最常见的MEFV突变(P369S、F479L、M680I(G/C)、M680I(G/A)、I692del、M694V、M694I、K695R、V726A、A744S、R761H、E148Q)的反向杂交分析(FMF StripAssay,Vienna lab,Vienna, Austria)。结果:12例特发性葡萄膜炎患者被纳入本研究。其中10人是女性。最小的病人是一个7岁的孩子,最大的是57岁。患者最常见的主诉是视力模糊,然后眼睛发红。1例患者为R761H杂合。对特发性葡萄膜炎患者中12种最常见的MEFV突变的遗传分析没有任何阳性结果。结论。根据对12种最常见的MEFV基因突变的分析,FMF并不是特发性葡萄膜炎的根本原因。另一方面,葡萄膜炎不可能是FMF的第一表现。
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Idiopathic uveitis and familial mediterranean Fever: is there any relationship?

Introduction. Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterized by attacks of fever and polyserositis. FMF is often associated with other autoimmune diseases such as rheumatoid arthritis, polyarteritis nodosa (PAN), and Behcet. Uveitis is an inflammatory process caused by underlying infectious and inflammatory disorders. This study investigates the probable relationship between idiopathic uveitis and FMF. Methods. Patients with idiopathic uveitis were analyzed for the 12 most common MEFV mutations (P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q) by a reverse hybridization assay (FMF StripAssay,Vienna lab,Vienna, Austria). Results. 12 patients with idiopathic uveitis were enrolled in this study. 10 of them were female. The youngest patient was a 7-year-old child and the oldest was 57. The most common complaints of patients were blurred vision and then eye redness. One patient was heterozygous for R761H. Genetic analysis of the 12 most common MEFV mutations in the patients with idiopathic uveitis didnot have any positive results. Conclusion. According to the analysis of the 12 most common MEFV gene mutations, FMF is not an underlying cause of idiopathic uveitis. On the other hand, uveitis merely could not be the first presentation of FMF.

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来源期刊
Autoimmune Diseases
Autoimmune Diseases IMMUNOLOGY-
CiteScore
6.10
自引率
0.00%
发文量
9
审稿时长
17 weeks
期刊最新文献
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