灵芝酸DM:一种治疗晚期前列腺癌的替代药物。

Benjamin M Johnson, Bently P Doonan, Faisal F Radwan, Azizul Haque
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引用次数: 23

摘要

前列腺癌是男性中最常见的癌症,在西方世界发病率和死亡率都很高。虽然传统疗法在清除早期癌症方面是有效的,但它们往往不能治疗晚期转移性疾病。因此,需要一种针对前列腺肿瘤生长和转移的有效治疗方法来缓解疾病并改善患者预后。天然提取物一直是最近研究的重点,特别是那些对健康组织的细胞毒性降低的提取物。在这篇综述中,我们讨论了一种潜在的候选者,灵芝酸,一种从灵芝蘑菇中提取的提取物,已经在多种癌症模型中进行了测试。有趣的是,在晚期转移性疾病中,灵芝酸DM (GA-DM)已显示出对雄激素依赖性和独立型前列腺癌细胞的毒性,这些细胞的破骨细胞生成减少。这篇综述将讨论GA-DM提取物目前的知识和治疗晚期前列腺癌的潜在益处。我们还将概述通过纳米颗粒靶向递送GA-DM,这将减少旁观者毒性并提高药物的有效性。对这种药物及其用途的进一步了解将推动天然化疗领域的发展,特别是在治疗晚期前列腺癌方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer.
Prostate cancer is the most commonly diagnosed cancer in men and accounts for significant morbidity and mortality in the western world. While traditional therapies are effective at clearing early stage cancer, they often fail to treat late stage metastatic disease. Thus, an effective therapy that targets prostate tumor growth and metastasis is desired for alleviating the disease and improving patient outcomes. Natural extracts have been the focus of recent investigation, particularly those with reduced cellular toxicity to healthy tissue. In this review, we discuss one potential candidate, ganoderic acid, an extract from the Ganoderma lucidum mushroom that has been tested in multiple cancer models. Interestingly, ganoderic acid DM (GA-DM) has shown toxicity to both androgen-dependent and independent prostate cancer cells with reduced osteoclastogenesis in late stage metastatic disease. This review will discuss the current knowledge on this GA-DM extract and the potential benefit in treating advanced prostate cancer. We will also provide an overview on the targeted delivery of GA-DM through nanoparticles that would reduce bystander toxicity and improve the drug's effectiveness. An improved understanding of this drug and its uses will advance the field of natural chemotherapeutics, particularly in treating advanced prostate cancer.
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