长期利培酮治疗诱导小鼠肝脂肪变性相关内脏脂肪:磁共振方法。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-04-27 DOI:10.1155/2014/429291
Florent Auger, Patrick Duriez, Françoise Martin-Nizard, Nicolas Durieux, Régis Bordet, Olivier Pétrault
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引用次数: 12

摘要

尽管非典型抗精神病药物(apd)在治疗精神障碍方面取得了重大进展,但它们仍然会引起代谢紊乱。我们的目的是表征利培酮治疗的代谢后果,并建立与无创磁共振标记物的联系,以便开发一种预测代谢综合征症状的工具。通过t1加权成像评估脂肪沉积和肝脏形态。分别采用有水抑制和无水抑制的磁共振光谱法测定脂肪酸组成和脂肪在组织中的积累。利培酮治疗导致体重增加,并伴有代谢紊乱,如高血糖状态、内脏脂肪组织(VAT)增加和肝脏脂肪沉积。利用亚甲基水比(MWR)和多不饱和指数(PUI)的相关性表明,体重增加、VAT和肝脏脂肪沉积同时增加,而多不饱和脂肪酸的数量减少。这些结果与肝脂肪变性状态一致。我们评估了MR技术检测apd引起的细微代谢紊乱的能力。因此,我们的模型和方法为研究apd的副作用提供了可能性,以改善精神分裂症患者的健康状况。
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Long-term risperidone treatment induces visceral adiposity associated with hepatic steatosis in mice: a magnetic resonance approach.

Although atypical antipsychotic drugs (APDs) have led to significant advances in the treatment of psychotic disorders, they still induce metabolic disturbances. We aimed at characterizing the metabolic consequences of a risperidone treatment and at establishing a link with noninvasive MR markers, in order to develop a tool for predicting symptoms of the metabolic syndrome. Fat deposition and liver morphometry were assessed by T1-weighted imaging. Fatty acid composition and fat accumulations in tissues were determined using MR spectroscopy with and without water suppression, respectively. Risperidone treatment induced a weight gain accompanied with metabolic disturbances such as hyperglycemic status, an increase in visceral adipose tissue (VAT), and liver fat depositions. Correlations using Methylene-Water Ratio (MWR) and Polyunsaturated Index (PUI) demonstrated a concomitant increase in the weight gain, VAT and liver fat depositions, and a decrease in the quantity of polyunsaturated fatty acids. These results were consistent with a hepatic steatosis state. We evaluated the ability of MR techniques to detect subtle metabolic disorders induced by APDs. Thus, our model and methodology offer the possibility to investigate APDs side effects in order to improve the health conditions of schizophrenic patients.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
期刊最新文献
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