Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpora
{"title":"5-羟色胺转运体5-HTT基因多态性与子宫内膜异位症在意大利患者群体中缺乏相关性。","authors":"Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpora","doi":"10.1186/1477-5751-13-12","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.</p><p><strong>Findings: </strong>A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls.</p><p><strong>Conclusions: </strong>Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.</p>","PeriodicalId":73849,"journal":{"name":"Journal of negative results in biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/1477-5751-13-12","citationCount":"2","resultStr":"{\"title\":\"Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population.\",\"authors\":\"Francesca Megiorni, Serena Resta, Deliar Yazdanian, Gabriele Cavaggioni, Claudia Lia, Pierluigi Benedetti Panici, Antonio Pizzuti, Maria Grazia Porpora\",\"doi\":\"10.1186/1477-5751-13-12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.</p><p><strong>Findings: </strong>A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls.</p><p><strong>Conclusions: </strong>Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.</p>\",\"PeriodicalId\":73849,\"journal\":{\"name\":\"Journal of negative results in biomedicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/1477-5751-13-12\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of negative results in biomedicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/1477-5751-13-12\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of negative results in biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/1477-5751-13-12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Lack of association between serotonin transporter 5-HTT gene polymorphism and endometriosis in an Italian patient population.
Background: The aim of this study was to determine whether the serotonin transporter gene (5-HTT), a key component in the control of the serotonergic system, is associated with endometriosis in an Italian population.
Findings: A case-control study, comprising 137 Italian patients with surgically confirmed endometriosis and 120 healthy controls, was carried out. 5-HTT genotypes (LL, SL and SS) were obtained by polymerase chain reaction and gel electrophoresis analysis. We found no overall difference in genotypic and allelic distributions of the 5-HTT gene between cases and controls.
Conclusions: Our results suggest that the 5-HTT L/S promoter polymorphism is not associated with susceptibility to endometriosis in the studied Italian patients.
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