胸部硬膜外畸胎瘤1例报告及文献复习。

Q3 Medicine Clinical Medicine Insights- Pathology Pub Date : 2014-06-09 eCollection Date: 2014-01-01 DOI:10.4137/CPath.S14723
Jennifer L Quon, Ryan A Grant, Anita J Huttner, Charles C Duncan
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引用次数: 4

摘要

目的:脊髓畸胎瘤是一种罕见的脊髓肿瘤,在这里,我们描述了一种更罕见的儿童胸椎硬膜外-小管内畸胎瘤。本文回顾了这些肿瘤的临床表现、管理和病理生理,以促进对这些病变的认识和指导治疗。方法:我们报告了一个21个月大的男孩,他表现出明显的痉挛,以及不能行走和满足运动里程碑。此外,我们提供脊柱畸胎瘤的文献回顾,包括他们的临床表现,检查,病理生理和潜在的遗传学。结果:脊柱MRI显示一个巨大的脊膜外肿瘤,从T3延伸到T10,具有不均匀的对比增强和严重的脊髓压迫。切除肿瘤后发现一个囊性肿块,其组织类似毛发、肌肉和软骨;病理证实为畸胎瘤。患儿最终获得了大体全切除,并获得了行走功能。结论:鉴于脊髓畸胎瘤是罕见的实体,可以表现出显著的神经损害,他们必须留在临床医生的鉴别。不幸的是,这些肿瘤的确切起源仍然没有定论,需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Thoracic epidural teratoma: case report and review of the literature.

Purpose: Spinal teratomas comprise a rare subset of spinal cord tumors, and here, we describe an even rarer childhood thoracic extradural-intracanalicular teratoma. The clinical presentation, management, and pathophysiology of these tumors are reviewed to promote recognition and guide treatment of these lesions.

Methods: We report the case of a 21-month-old boy who presented with marked spasticity, as well as failure to ambulate and meet motor milestones. Additionally, we provide a literature review of spinal teratomas, including their clinical presentation, work-up, pathophysiology, and underlying genetics.

Results: An MRI of the spine revealed a large dorsal epidural tumor extending from T3 to T10 with heterogeneous contrast enhancement and severe spinal cord compression. The tumor was resected revealing a cystic mass with tissue resembling hair, muscle, as well as cartilage; pathology confirmed the diagnosis of teratoma. Gross total resection was achieved, and the child eventually gained ambulatory function.

Conclusions: Given that spinal teratomas are rare entities that can present with significant neurologic compromise, they must remain on clinicians' differentials. Unfortunately, the exact origin of these tumors remains inconclusive and requires further investigation.

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CiteScore
1.90
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审稿时长
4 weeks
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