残留阴性症状区分临床稳定的精神分裂症和双相情感障碍患者的认知表现。

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-06-12 DOI:10.1155/2014/785310
Rajeev Krishnadas, Seethalakshmi Ramanathan, Eugene Wong, Ajita Nayak, Brian Moore
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引用次数: 6

摘要

在双相情感障碍和精神分裂症患者中已经显示出不同领域的认知缺陷。本研究的目的是检验残余精神病理学是否解释了临床稳定的精神分裂症和双相情感障碍患者之间认知功能的差异。我们比较了25例缓解期精神分裂症患者和25例常郁型双相情感障碍患者的注意力、视觉和言语记忆以及执行功能测试的表现与25名健康对照者。使用中介分析来观察残余精神病理学是否可以解释患者组之间认知功能的差异。在大多数认知测试中,两组患者的表现都明显差于健康对照组。双相情感障碍患者表现出较轻的认知缺陷,但在质量上与精神分裂症患者相似。残留的阴性症状介导了两组在认知测试中的表现差异。残留的一般精神病症状和更大的抗精神病药物剂量都不能解释这种关系。与双相情感障碍相比,精神分裂症患者额叶皮质神经生理缺陷更大,这可以解释患者组之间存在的剩余负性和认知缺陷的共同差异。进一步的纵向研究可能会深入了解这些缺陷背后的病理生理机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Residual negative symptoms differentiate cognitive performance in clinically stable patients with schizophrenia and bipolar disorder.

Cognitive deficits in various domains have been shown in patients with bipolar disorder and schizophrenia. The purpose of the present study was to examine if residual psychopathology explained the difference in cognitive function between clinically stable patients with schizophrenia and bipolar disorder. We compared the performance on tests of attention, visual and verbal memory, and executive function of 25 patients with schizophrenia in remission and 25 euthymic bipolar disorder patients with that of 25 healthy controls. Mediation analysis was used to see if residual psychopathology could explain the difference in cognitive function between the patient groups. Both patient groups performed significantly worse than healthy controls on most cognitive tests. Patients with bipolar disorder displayed cognitive deficits that were milder but qualitatively similar to those of patients with schizophrenia. Residual negative symptoms mediated the difference in performance on cognitive tests between the two groups. Neither residual general psychotic symptoms nor greater antipsychotic doses explained this relationship. The shared variance explained by the residual negative and cognitive deficits that the difference between patient groups may be explained by greater frontal cortical neurophysiological deficits in patients with schizophrenia, compared to bipolar disorder. Further longitudinal work may provide insight into pathophysiological mechanisms that underlie these deficits.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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