Anna Dietrich-Muszalska, Justyna Kopka, Bogdan Kontek
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引用次数: 10
摘要
背景。精神分裂症患者的氧化应激可能部分由抗精神病药物治疗引起。本研究旨在探讨黑果野莓(Aronox)多酚类化合物对齐拉西酮诱导的血浆脂质过氧化的影响。方法。脂质过氧化通过硫代巴比妥酸活性物质(TBARS)水平测定。健康人血浆样品用齐拉西酮(40 ng/ml;139 ng / ml;和250 ng/ml)单独和与Aronox (5 ug/ml;50微克/毫升)。结果。我们观察到齐拉西酮(40 ng/ml;139 ng / ml;和250 ng/ml)(孵育24 h后分别P = 7.0 × 10(-4)、P = 1.6 × 10(-3)和P = 2.7 × 10(-3)),齐拉西酮引起的Aronox脂质过氧化显著降低。齐拉西酮(40 ng/ml)血浆孵育24小时后;139 ng / ml;50 ug/ml Aronox存在时,TBARS水平显著降低:P = 6.5 × 10(-8), P = 7.0 × 10(-6), P = 3.0 × 10(-5)。结论。阿罗诺克斯引起由齐拉西酮引起的脂质过氧化明显减少。
Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone.
Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidone in vitro. Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml). Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation: P = 7.0 × 10(-4), P = 1.6 × 10(-3), and P = 2.7 × 10(-3), resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased: P = 6.5 × 10(-8), P = 7.0 × 10(-6), and P = 3.0 × 10(-5), respectively. Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone.
期刊介绍:
Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.