治疗代谢综合征的N-(6-(4-(哌嗪-1-基)苯氧基)吡啶-3-基)苯磺酰胺衍生物的合成

International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-12-22 DOI:10.1155/2013/201580
Nabajyoti Deka, Swapnil Bajare, Jessy Anthony, Amrutha Nair, Anagha Damre, Dharmeshkumar Patel, Chandrika B-Rao, H Sivaramakrishnan, Shivaprakash Jagalur Mutt, Chandan Wilankar, Rosalind Marita
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引用次数: 0

摘要

代谢综合征是一种广泛流行的多因素疾病,与心血管疾病和2型糖尿病的风险增加有关。胰岛素抵抗引起的高血浆胰岛素和葡萄糖水平是代谢紊乱的主要组成部分。噻唑烷二酮(TZDs)是一种有效的PPARγ配体,被用作治疗2型糖尿病的胰岛素增敏剂。它们是有效的胰岛素增敏剂,但由于肝毒性等副作用,迫切需要一种更安全的tzd替代品。本文报道了N-(6-(4-(哌嗪-1-基)苯氧基)吡啶-3-基)苯磺酰胺衍生物的合成,作为胰岛素抵抗的替代药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome.

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.

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期刊介绍: International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.
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