微波辅助合成及抗炎、抗菌和抗真菌二氢嘧啶衍生物的生物学评价。

International Journal of Medicinal Chemistry Pub Date : 2013-01-01 Epub Date: 2013-04-15 DOI:10.1155/2013/197612

Anjna Bhatewara, Srinivasa Rao Jetti, Tanuja Kadre, Pradeep Paliwal, Shubha Jain

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引用次数: 12

摘要

在无溶剂微波照射下，以哌啶为催化剂，通过初始Knoevenagel，随后加成，最后将醛、氰乙酸乙酯和硝酸胍环化，获得了一种简单的制备芳基和杂芳基取代二氢嘧啶酮的方法。合成的化合物具有良好的抗炎、抗菌和抗真菌活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Microwave-assisted synthesis and biological evaluation of dihydropyrimidinone derivatives as anti-inflammatory, antibacterial, and antifungal agents.

A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.

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International Journal of Medicinal Chemistry CHEMISTRY, MEDICINAL-

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期刊介绍： International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis. International Journal of Medicinal Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of chemistry associated with drug discovery, design, and synthesis.