心脏手术治疗终末期肾病:非裔美国患者的预后更差吗?

Open journal of cardiovascular surgery Pub Date : 2013-08-11 eCollection Date: 2013-01-01 DOI:10.4137/OJCS.S11395
Jonathan O Nwiloh, Chamberlain I Obialo
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引用次数: 2

摘要

终末期肾病患者(ESRD)的心脏直视手术的一般结果已经得到了充分的证明。然而,目前尚不清楚非裔美国人亚组是否有较差的心脏手术后长期生存率,他们获得先进医疗服务的机会较少,ESRD患病率较高。1996年至2010年间,150名非裔美国患者在一家城市社区医院接受了由一名外科医生进行的心脏直视手术,其中30人被确定患有ESRD,并在手术前进行了慢性维持性血液透析。回顾性分析两组的临床和结局资料。患者的基线人口学特征没有显著差异,但ESRD队列显示外周血管和心血管疾病的患病率明显更高[P < 0.001]。与非esrd组相比,预测logistic EuroSCORE为16.4%比9.4%,[P < 0.001],观察到的30天手术死亡率分别为16.6%比4.2% [P < 0.02]。孤立冠状动脉旁路移植术的手术死亡率分别为20.8%和3.0%。ESRD组和非ESRD组术后5年和10年生存率分别为40%和25%,分别为72%和57% [P < 0.01]。基于术前风险评分,ESRD患者的手术死亡率和生存率比非ESRD患者更差。虽然我们的ESRD患者的手术死亡率很高,但长期生存率与美国肾脏数据系统和日本ESRD队列的报告相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Heart surgery in end-stage renal disease: is outcome worse for african american patients?

General results of open heart surgery in end-stage renal disease patients (ESRD) have been well-documented. However, it is unknown if the African American subgroup with known decreased access to advanced healthcare services and a higher prevalence rate of ESRD have a worse long-term survival after heart surgery. Thirty of 150 African American patients who underwent open heart surgery by a single surgeon at an urban community hospital between 1996 and 2010 were identified to have ESRD and were on chronic maintenance hemodialysis prior to surgery. Clinical and outcome data from both groups were retrospectively analyzed. There were no significant differences in the baseline demographic characteristics of the patients, but the ESRD cohort showed a significantly higher prevalence of peripheral vascular and cardiovascular diseases [P < 0.001]. Compared to the non-ESRD subjects, the predicted logistic EuroSCORE was 16.4% vs. 9.4%, [P < 0.001], while the observed 30 days operative mortality was 16.6% vs. 4.2% [P < 0.02], respectively. In isolated coronary artery bypass graft cases, operative mortality was 20.8% and 3.0%, respectively. The 5- and 10-year post-surgery survival was 40% and 25% vs. 72% and 57% [P < 0.01], respectively, in the ESRD and non-ESRD groups. Operative mortality and survival was worse in ESRD patients compared to non-ESRD patients based on their preoperative risk scores. Although the operative mortality of our ESRD patients was high, long-term survival was comparable to reports from both the United States Renal Data System and a Japanese ESRD cohort.

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