性别认同障碍与精神分裂症:具有共同因果机制的神经发育障碍?

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-12-04 DOI:10.1155/2014/463757
Ravi Philip Rajkumar
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引用次数: 42

摘要

性别认同障碍(GID),最近更名为性别焦虑症(GD),是一种罕见的疾病,其特征是性别认同与生理性别之间的不一致。临床证据表明,GID患者发生精神分裂症的比率高于一般人群,并且GID患者可能具有类似精神分裂症的人格特征。相反,精神分裂症患者可能会经历性别认同和性别角色感知的改变。神经生物学研究,包括脑成像和手指长度比和利手性的研究,表明这两种疾病都与大脑性别二态性的改变和大脑侧化的改变有关。各种机制,如弓形虫感染、脑源性神经营养因子(BDNF)水平降低、儿童早期逆境以及与自闭症谱系障碍的联系,可能在一定程度上解释这种重叠。讨论了这一关联对进一步研究的意义。
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Gender identity disorder and schizophrenia: neurodevelopmental disorders with common causal mechanisms?

Gender identity disorder (GID), recently renamed gender dysphoria (GD), is a rare condition characterized by an incongruity between gender identity and biological sex. Clinical evidence suggests that schizophrenia occurs in patients with GID at rates higher than in the general population and that patients with GID may have schizophrenia-like personality traits. Conversely, patients with schizophrenia may experience alterations in gender identity and gender role perception. Neurobiological research, including brain imaging and studies of finger length ratio and handedness, suggests that both these disorders are associated with altered cerebral sexual dimorphism and changes in cerebral lateralization. Various mechanisms, such as Toxoplasma infection, reduced levels of brain-derived neurotrophic factor (BDNF), early childhood adversity, and links with autism spectrum disorders, may account for some of this overlap. The implications of this association for further research are discussed.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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