机器人前列腺切除术在较大的前列腺中有更好的结果,PSA密度是生化复发的一个强有力的预测指标。

IF 2.3 Q3 ONCOLOGY Prostate Cancer Pub Date : 2014-01-01 Epub Date: 2014-12-15 DOI:10.1155/2014/763863
S Bishara, N Vasdev, T Lane, G Boustead, J Adshead
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引用次数: 5

摘要

目标。本研究的目的是比较15例(4.3%)患者(≥75 g)和较小(0.2 g)患者的机器人辅助腹腔镜前列腺切除术(RALP)的结果。前列腺大小≥75 g与最终病理Gleason评分较低(P = 0.004)和病理分期较低(P = 0.02)相关,但与住院时间延长相关(P = 0.05)。当术后PSA >0.1 (P = 0.001)和PSA >0.2 (P = 0.039)时,PSAD独立预测生化复发(BCR)。在这两种情况下,PSA不再是一个重要的独立预测因子。结论。大前列腺RALP≥75 g;
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Robotic Prostatectomy Has a Superior Outcome in Larger Prostates and PSA Density Is a Strong Predictor of Biochemical Recurrence.

Objectives. The aims of this study were to compare the outcomes of robotic assisted laparoscopic prostatectomy (RALP) between patients who had larger (≥75 g) and smaller (<75 g) prostates and to evaluate the performance of PSA density (PSAD) in determining the oncological outcome of surgery. Methods and Materials. 344 patients who underwent RALP at a single institution were included in the study. Preoperative risk factors and postoperative, oncological outcomes, erectile function, and continence status were recorded prospectively. Results. During a mean follow-up of 20 months, biochemical recurrence (PSA > 0.2) was observed in 15 patients (4.3%). Prostate size ≥75 g was associated with lower Gleason score on final pathology (P = 0.004) and lower pathological stage (P = 0.02) but an increased length of hospital stay (P = 0.05). PSAD on binary logistic regression independently predicted biochemical recurrence (BCR) when defined as postoperative PSA >0.1 (P = 0.001) and PSA >0.2 (P = 0.039). In both instances PSA was no longer a significant independent predictor. Conclusions. RALP in large prostates (≥75 g, <150 g) is as safe as RALP in smaller prostates and is associated with a lower pathological grade and stage. Higher PSAD is independently associated with BCR and is superior to PSA as a predictor of BCR after RALP.

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来源期刊
Prostate Cancer
Prostate Cancer ONCOLOGY-
CiteScore
2.70
自引率
0.00%
发文量
9
审稿时长
13 weeks
期刊介绍: Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.
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