Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D'Elios, Alberto Bosi, Mario M D'Elios
{"title":"移植物抗宿主病患者皮肤CD30(+) T细胞和循环可溶性CD30水平升高。","authors":"Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D'Elios, Alberto Bosi, Mario M D'Elios","doi":"10.1007/s13317-013-0054-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).</p><p><strong>Methods: </strong>Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.</p><p><strong>Results: </strong>Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.</p><p><strong>Conclusion: </strong>These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.</p>","PeriodicalId":8655,"journal":{"name":"Auto-Immunity Highlights","volume":"5 1","pages":"21-6"},"PeriodicalIF":0.0000,"publicationDate":"2013-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13317-013-0054-7","citationCount":"5","resultStr":"{\"title\":\"Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease.\",\"authors\":\"Amedeo Amedei, Nicola Pimpinelli, Alessia Grassi, Chiara Della Bella, Elena Niccolai, Simona Brancati, Marisa Benagiano, Sofia D'Elios, Alberto Bosi, Mario M D'Elios\",\"doi\":\"10.1007/s13317-013-0054-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).</p><p><strong>Methods: </strong>Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.</p><p><strong>Results: </strong>Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.</p><p><strong>Conclusion: </strong>These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.</p>\",\"PeriodicalId\":8655,\"journal\":{\"name\":\"Auto-Immunity Highlights\",\"volume\":\"5 1\",\"pages\":\"21-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s13317-013-0054-7\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Auto-Immunity Highlights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13317-013-0054-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2014/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Auto-Immunity Highlights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13317-013-0054-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/6/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease.
Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).
Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.
Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.
Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
