A A Shabalina, L A Liapina, D L Rochev, M V Kostyreva, M M Tanashian, Z A Suslina
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引用次数: 0
摘要
体外研究了含亮氨酸的甘脯氨酸、Pro-Gly-Pro-Leu和亮氨酸- pro - gly - pro在脂质代谢紊乱患者血液中的降脂、纤溶和抗凝作用。发现了甘脯氨酸的降脂作用及其在人体血液中减少纤维蛋白聚合和增加纤维蛋白解聚的能力。通过脂质依赖性磷脂酶A2的调节，提出了多肽的脂溶作用的可能机制。
[In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood].
The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.
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