极端乳酸性酸中毒B型与二甲双胍治疗相关。

NDT Plus Pub Date : 2011-12-01 Epub Date: 2011-09-14 DOI:10.1093/ndtplus/sfr110

Andreas Pikwer, Einar Vernersson, Anders Frid, Gunnar Sterner

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引用次数: 6

摘要

二甲双胍的清除完全通过肾脏，血浆浓度升高可引起乳酸性酸中毒。我们报告一例严重乳酸酸中毒(pH 6.60)发生与表面正常治疗剂量的二甲双胍在设置急性肾功能衰竭。持续的静脉-静脉血液滤过使血浆二甲双胍浓度从出现时的266 lmol/L降至21 h后的68 lmol/L。病人好转得很快。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Extreme lactic acidosis type B associated with metformin treatment.

The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations can cause lactic acidosis. We report a case of severe lactic acidosis (pH 6.60) occuring with ostensibly normal therapeutic doses of metformin in the setting of acute renal failure. Continuous veno-venous haemodiafiltration decreased plasma metformin concentrations from 266 lmol/L at presentation to 68 lmol/L, 21 h later. The patient improved rapidly.

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