儿童期(从婴儿期到学龄)食物过敏。

Chemical immunology and allergy Pub Date : 2015-01-01 Epub Date: 2015-05-21 DOI:10.1159/000371666
Marcel M Bergmann, Philippe A Eigenmann
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引用次数: 6

摘要

食物过敏是一种潜在的危及生命的疾病,影响了近10%的儿童,在过去的几十年里发病率不断上升。它被定义为对食物的免疫反应,其发病机制可能是IgE介导的、IgE与非IgE混合介导的或非IgE介导的。所有的食物都可能导致食物过敏,但少数食物会导致绝大多数的过敏反应。良好的临床病史对准确诊断至关重要。过敏试验,包括皮肤点刺试验和特异性IgE抗体的测量,在IgE介导或混合过敏的情况下是有用的工具,但尚未显示对食物的延迟过敏反应有任何帮助。
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Food allergy in childhood (infancy to school age).

Food allergy is a potentially life-threatening condition affecting almost 10% of children, with an increasing incidence in the last few decades. It is defined as an immune reaction to food, and its pathogenesis may be IgE mediated, mixed IgE and non-IgE mediated, or non-IgE mediated. Potentially all foods can cause food allergy, but a minority of foods are responsible for the vast majority of reactions reported. A good clinical history is crucial for an accurate diagnosis. Allergy tests, including the skin prick test and measurement of specific IgE antibodies, are useful tools in the case of IgE-mediated or mixed allergy but have not been shown to be of any help in delayed allergic reactions to foods.

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Historical background, definitions and differential diagnosis. Immunological basis of food allergy (IgE-mediated, non-IgE-mediated, and tolerance). Food allergens: molecular and immunological aspects, allergen databases and cross-reactivity. Epidemiology: international point of view, from childhood to adults, food allergens. Food allergy in childhood (infancy to school age).
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