舒尼替尼治疗晚期肾细胞癌疗效的预测因素:我们真的取得进展了吗?

IF 0.1 4区 医学 Q4 Medicine Analytical and Quantitative Cytopathology and Histopathology Pub Date : 2015-02-01
Maristella Bianconi, Luca Faloppi, Michele Del Prete, Riccardo Giampieri, Alessandro Bittoni, Antonio Lopez-Beltran, Marina Scarpelli, Liang Cheng, Mario Scartozzi, Stefano Cascinu, Rodolfo Montironi
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引用次数: 0

摘要

肾细胞癌是一种侵袭性肿瘤,常在晚期偶然诊断(局部或转移)。舒尼替尼是一种抑制多种受体酪氨酸激酶的小分子,主要针对血管生成途径。舒尼替尼主要用于一线治疗,但不同患者的反应差异很大。因此,迫切需要找到能够确定患者是否对治疗有反应的预测因素,从而避免不必要的毒性。在这篇报告中,我们回顾了目前正在研究和更有希望进入临床实践的临床、病理和分子预测因素的文献。
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Predictive factors for sunitinib treatment response in advanced renal cell carcinoma: are we really making steps forward?

Renal cell carcinoma is an aggressive neoplasm, frequently diagnosed incidentally in an advanced stage (local or metastatic). Sunitinib is a small molecule that inhibits multiple receptor tyrosine kinases, mainly directed against the angiogenic pathway. Sunitinib is largely used in first-line treatment, but response varies widely among patients. Thus, there is an urgent need to find predictive factors able to determine whether or not a patient would respond to treatment, thereby avoiding unnecessary toxicities. In this report we review the literature focusing on clinical, pathological, and molecular predictive factors currently being studied and more promising to enter clinical practice.

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期刊介绍: AQCH is an Official Periodical of The International Academy of Cytology and the Italian Society of Urologic Pathology.
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