Ying Zhang, Thabitha P Shareena Dasari, Hua Deng, Hongtao Yu
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引用次数: 214
摘要
纳米粒子(AuNPs)和离子形式的金已经被研究用于抗生素活性。一些Au (I & III)离子的有机配合物具有抗菌作用。AuNPs具有抗真菌作用，但其抑菌活性的结果相互矛盾。我们总结了这些出版物，发现AuNPs通常不具有杀菌作用，或者仅在高浓度下具有弱杀菌作用。然而，AuNPs具有杀菌作用的原因可能是由于共存的化学物质的杀菌活性没有完全从AuNPs中去除:金离子，表面涂层剂和参与合成的化学物质。AuNPs还可以作为抗生素的载体或递送载体，从而增强抗生素的杀菌效果。
Antimicrobial Activity of Gold Nanoparticles and Ionic Gold.
Gold, in both nanoparticle (AuNPs) and ionic forms, has been studied for antibiotic activities. Some of the organic complexes of Au (I & III) ions are antibacterial. AuNPs are antifungal, but with conflicting results on their antibacterial activity. We summarized these publications and found that AuNPs are generally not bactericidal, or only weakly at high concentrations. However, the reason AuNPs appear to be bactericidal is possibly due to the bactericidal activity of co-existing chemicals not completely removed from AuNPs: gold ions, surface coating agents, and chemicals involved in the synthesis. AuNPs can also act as carriers or delivery vehicles of antibiotics, thus enhancing the bactericidal effect of the antibiotics.
期刊介绍：
Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.
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