每天服用三次哌唑嗪治疗与PTSD相关的闪回:一例报告。

The Mental Health Clinician Pub Date : 2022-08-23 eCollection Date: 2022-08-01 DOI:10.9740/mhc.2022.08.267
Christie Richardson, Alexander Swartz, Martin Forsberg
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引用次数: 1

摘要

普拉唑嗪是一种α -1肾上腺素受体拮抗剂,因其在标签外用于治疗PTSD患者的噩梦而被精神健康提供者广泛知晓。哌唑嗪具有亲脂性,可穿过血脑屏障对抗中枢神经系统中的α -1受体,潜在地减少PTSD引起的自主神经觉醒。有许多案例报告描述了分别在夜间和白天服用哌唑嗪可以减少创伤后应激障碍患者的噩梦和白天闪回。本病例报告说明解决与慢性创伤后应激障碍的闪回与吡唑嗪每天服用3次。由于哌唑嗪的半衰期仅为2 ~ 3小时,即使每天两次给药也可能导致两次给药之间出现突破性症状。本病例提出了一种独特的哌唑嗪给药策略,并需要进一步研究利用多剂量的哌唑嗪治疗PTSD。
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Prazosin dosed 3 times a day to treat flashbacks related to PTSD: A case report.

Prazosin is an alpha-1 adrenergic receptor antagonist widely known by mental health providers for its off-label use for nightmares in patients with PTSD. Prazosin is lipophilic and crosses the blood-brain barrier to antagonize alpha-1 receptors in the central nervous system, potentially reducing autonomic arousal caused by PTSD. There have been numerous case reports describing the reduction of nightmares and daytime flashbacks due to PTSD with prazosin dosed at night and during the day, respectively. This case report illustrates the resolution of flashbacks related to chronic PTSD with prazosin dosed 3 times a day. As the half-life of prazosin is only 2 to 3 hours, even a twice daily dosing regimen may lead to breakthrough symptoms between doses. This case proposes a unique dosing strategy for prazosin and need for further research utilizing multiple daily doses of prazosin in the treatment of PTSD.

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