加强接种与2次接种BNT162b2免疫减弱的比较。

IF 4.3 4区医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2022-06-17 eCollection Date: 2022-08-01 DOI:10.4110/in.2022.22.e31

Jiwon Jung, Ji Yeun Kim, Ji-Soo Kwon, Sung-Cheol Yun, Sung-Han Kim

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Comparison of Waning Immunity Between Booster Vaccination and 2-Dose Vaccination With BNT162b2.

S1 specific IgG Ab was measured using an in-house developed ELISA, and the data are presented in IU/ml. The interferon-gamma ELISPOT assay was used to assess the SARS-CoV-2-specific T cell response in isolated PBMCs. T cells were stimulated using SARS-CoV-2 spike-overlapping peptides (Miltenyi Biotec, Bergisch Gladbach, Germany), and the number of spot-forming cells per 5.0×10 5 PBMCs were counted with an automated ELISPOT reader (AID iSPOT; Autoimmun Diagnostika GmbH, Strassberg, Germany). A linear mixed regression model was used to compare the slope from the peak Ab titer to the lowest Ab titer (23 wk after the second vaccination) and the slope from the peak Ab titer

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来源期刊

Immune Network Immunology and Microbiology-Immunology

CiteScore

2.90

自引率

3.30%

发文量

期刊介绍： Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity