Christian M Chaheine, Conner J Song, Paul T Gladen, Daniel Romo
{"title":"焦谷氨酸衍生物的对映选择性迈克尔质子转移内酰胺化:二甲基-(S,E)-5-氧-3-苯乙烯-1-酰基吡咯烷-2,2-二羧酸酯的合成。","authors":"Christian M Chaheine, Conner J Song, Paul T Gladen, Daniel Romo","doi":"10.15227/orgsyn.098.0194","DOIUrl":null,"url":null,"abstract":"A. Dimethyl 2-amino((4-methylphenyl)sulfonamido)malonate (2). To a single-necked, 500 mL round-bottomed flask containing a football-shaped, teflon-coated stir bar (5 cm) and fitted with a 24/40 glass, threaded gas-inlet adapter with a silicone/PTFE septa (Figure 1A) (Note 2), in-turn connected via chemically resistant tubing to a vacuum/nitrogen manifold is added commercially available dimethyl aminomalonate hydrochloride (1, 12.5 g, MeO2C CO2Me NH2 •HCl Ts2O, NEt3 THF, 0 to 23 °C MeO2C CO2Me NHTs","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463714/pdf/nihms-1832364.pdf","citationCount":"0","resultStr":"{\"title\":\"Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(<i>S,E</i>)-5-oxo-3-styryl-1-tosylpyrrolidine-2,2-dicarboxylate.\",\"authors\":\"Christian M Chaheine, Conner J Song, Paul T Gladen, Daniel Romo\",\"doi\":\"10.15227/orgsyn.098.0194\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A. Dimethyl 2-amino((4-methylphenyl)sulfonamido)malonate (2). To a single-necked, 500 mL round-bottomed flask containing a football-shaped, teflon-coated stir bar (5 cm) and fitted with a 24/40 glass, threaded gas-inlet adapter with a silicone/PTFE septa (Figure 1A) (Note 2), in-turn connected via chemically resistant tubing to a vacuum/nitrogen manifold is added commercially available dimethyl aminomalonate hydrochloride (1, 12.5 g, MeO2C CO2Me NH2 •HCl Ts2O, NEt3 THF, 0 to 23 °C MeO2C CO2Me NHTs\",\"PeriodicalId\":19576,\"journal\":{\"name\":\"Organic Syntheses\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463714/pdf/nihms-1832364.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic Syntheses\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15227/orgsyn.098.0194\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic Syntheses","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15227/orgsyn.098.0194","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(S,E)-5-oxo-3-styryl-1-tosylpyrrolidine-2,2-dicarboxylate.
A. Dimethyl 2-amino((4-methylphenyl)sulfonamido)malonate (2). To a single-necked, 500 mL round-bottomed flask containing a football-shaped, teflon-coated stir bar (5 cm) and fitted with a 24/40 glass, threaded gas-inlet adapter with a silicone/PTFE septa (Figure 1A) (Note 2), in-turn connected via chemically resistant tubing to a vacuum/nitrogen manifold is added commercially available dimethyl aminomalonate hydrochloride (1, 12.5 g, MeO2C CO2Me NH2 •HCl Ts2O, NEt3 THF, 0 to 23 °C MeO2C CO2Me NHTs
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
