肾移植旅游的移植物和患者疗效:单中心经验。

Avicenna Journal of Medicine Pub Date : 2022-08-16 eCollection Date: 2022-07-01 DOI:10.1055/s-0042-1750715
Abdulrahman Altheaby, Kenana Owaidah, Aljowharah Alotaibi, Rahaf Salem, Rihaf Algain, Areij Alotaibi, Ahmad Alnasrullah, Mohammed F Shaheen, Mohammed Tawhari, Mohamad Abdulgadir
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引用次数: 0

摘要

背景器官捐献者和等待移植的病人之间的供需错配导致了移植旅游的增长。这种移植被认为是不道德和非法的,因为它通常是在恶劣的环境中进行的,而且感染、血管和免疫并发症的风险较高。方法 在这项单一中心的回顾性队列研究中,我们将接受移植旅游的患者与接受本地移植的患者进行了比较,并在 2015 年 1 月至 2018 年 12 月期间在我院进行了随访。结果 共纳入 254 名本地移植患者和 60 名移植旅游组患者。移植旅游组受者更年轻,但两组在性别、体重指数、糖尿病和高血压方面相似。移植旅游组受者的移植物功能延迟率(18.3% 对 6.3%,P 0.005)和急性排斥率(40% 对 7.9%,P 0.005)明显更高。必须加大力度,向患者宣传移植旅游的临床风险和伦理因素,以减少移植旅游。此外,还必须采取措施增加死亡供体库的数量,为患者提供更好的替代选择。
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Graft and Patient Outcomes of Kidney Transplant Tourism: A Single-Center Experience.

Background  The supply-demand mismatch between organ donor and patient waiting for transplant has led to the growth of transplant tourism. This type of transplant is considered unethical and illegal, as it is usually performed in poor environments and carries a higher risk of infectious, vascular, and immunological complications. Methods  In this single-centered retrospective cohort study, we compared patients who underwent transplant tourism to patients who were transplanted locally and followed up in our hospital from January 2015 to December 2018. Result  A total of 254 local transplants and 60 patients from the transplant tourism group were included. Transplant tourism recipients were younger otherwise both groups were similar in gender, body mass index, diabetes, and hypertension. Recipients in the transplant tourism group had a significantly higher rate of delayed graft function (18.3% vs. 6.3%, p 0.005), acute rejection (40% vs. 7.9%, p  < 0.001), and higher posttransplant infection in general. With more urological complications and higher graft failure at 3-years' follow-up (11.7% vs. 0.8%, p  < 0.001). Conclusion  Transplant tourism is associated with a higher risk of infection and poor graft outcomes. Extra efforts are required to cut down transplant tourism by educating patients about its clinical risk and ethical considerations. In addition, measures to increase the number of deceased donor pool to provide a better alternative options for patients are essential.

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