肺鳞状细胞癌伴鳞片样样生长。

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2022-08-01 DOI:10.32074/1591-951X-450
Claudio Guerrieri, Mark Lindner, Joanna Sesti, Abhishek Chakraborti, Rachel Hudacko
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引用次数: 0

摘要

我们报告一例罕见的外周鳞状细胞癌(SCC)的肺,其中大部分肿瘤显示为“鳞状”生长模式。肿瘤细胞也沿着肺细胞和基底膜之间的肺泡壁生长,这种形式使人联想到“页状”扩散模式。肿瘤细胞呈鳞状标记物p63、p40阳性。TTF-1和CK7突出显示残留的非肿瘤性肺细胞,这些肺细胞要么覆盖在鳞状肿瘤细胞上,要么由肿瘤填充肺泡间隙形成的衬排假腺结构。CK7也染色肿瘤细胞,尽管是局部和微弱的,这在周围性肺鳞状细胞癌中并不罕见。肿瘤细胞对TTF-1(克隆8G7G3/1)呈阴性,但对特异性较低的克隆SPT24表现出局灶性弱反应。浸润面积为2.5 mm,肿瘤包括鳞片样叶成分的总尺寸为9.0 mm。即使侵入性成分小于0.5 cm,根据现有的分期标准,唯一的选择是将其分期为pT1a。由于目前的分期系统没有考虑到肺SCC的非侵袭性鳞状细胞成分,因此对这种变异的日益认识可能需要将其纳入肺癌的分类和病理分期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pulmonary squamous cell carcinoma with a lepidic-pagetoid growth pattern.

We report a rare case of a peripheral squamous cell carcinoma (SCC) of the lung in which most of the tumor displayed a "lepidic" growth pattern. The tumor cells also appeared to grow along the alveolar walls between the overlying pneumocytes and underlying basement membrane, a form reminiscent of the "pagetoid" mode of spread. The neoplastic cells were positive for the squamous markers p63 and p40. TTF-1 and CK7 highlighted residual non-neoplastic pneumocytes, which either covered the lepidic tumor cells or lined pseudoglandular formations created by the filling of alveolar spaces by the tumor. CK7 also stained the tumor cells, albeit focally and weakly, a not uncommon finding in peripheral lung SCC. The tumor cells were negative for TTF-1 (clone 8G7G3/1), but did show focal weak reactivity with the less specific clone SPT24. The invasive area measured 2.5 mm while the overall size of the tumor including the lepidic-pagetoid component was 9.0 mm. Even though the invasive component was < 0.5 cm, the only option according to existing staging criteria was to stage it as pT1a. Since the current staging system does not account for the non-invasive lepidic component of pulmonary SCC, the increasing awareness of this variant may require its inclusion within the classification and pathological staging of lung carcinoma.

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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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