不明原因的儿科急性肝炎(非甲型-戊型肝炎)。

Q2 Medicine Infezioni in Medicina Pub Date : 2022-09-01 eCollection Date: 2022-01-01 DOI:10.53854/liim-3003-4
Nasim Asadi Faezi, Bahareh Mehramouz, Sepehr Taghizadeh, Pasquale Pagliano, Hossein Samadi Kafil
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引用次数: 0

摘要

自2021年10月以来,在美国、欧洲以及最近在亚洲和中美洲报告了几例急性肝炎聚集性和个例。对常见病毒性肝炎病原体(HAV、HBV、HCV、HDV和HEV)的实验室调查结果为阴性,因此使用“急性非HepA-E肝炎”一词来描述这种情况。截至2022年6月24日,世卫组织报告了世卫组织5个区域33个国家的920例不明来源严重急性肝炎可能病例。自2022年5月27日的上一份报告以来,新增了270例可能病例,其中包括来自四个新国家的病例,其中一些人也被发现对SARS-CoV-2呈阳性。所有患者均出现呕吐、腹泻、黄疸、腹痛等症状。患者肝酶明显升高。到目前为止,尚未发现与SARS-CoV-2或其疫苗有关。然而,怀疑的原因是腺病毒,包括其基因组变异,因为其发病机制和实验室调查有积极的联系。在进一步的证据出现之前,卫生预防措施可能有助于防止其传播。
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Acute hepatitis (Non Hepa A-E) of unknown origin among pediatrics.

Several clusters and individual cases of acute hepatitis have been reported in the US, Europe and recently in Asia and Central America since October 2021. A laboratory investigation of the common viral hepatitis agents (HAV, HBV, HCV, HDV and HEV) yielded negative results prompting the use of the term "acute non HepA-E hepatitis" to describe this condition. As of 24 June of 2022, WHO have reported 920 probable cases of severe acute hepatitis of unknown origin among pediatrics in 33 countries in five WHO regions. Since the previous reports on 27 May 2022, 270 new probable cases have been increased, including from four new countries, some of whom were also found to be positive for SARS-CoV-2. All the patients showed symptoms such as vomiting, diarrhea, jaundice, and abdominal pain. The patients' liver enzymes were remarkably increased. No connection with SARS-CoV-2 or its vaccine has been found so far. However, the suspected cause is adenovirus, including its genomic variations, because its pathogenesis and laboratory investigations have been positively linked. Until further evidence emerges, hygiene precautions could be helpful to prevent its spread.

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来源期刊
Infezioni in Medicina
Infezioni in Medicina Medicine-Infectious Diseases
CiteScore
8.40
自引率
0.00%
发文量
62
期刊介绍: The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.
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