希腊住院COVID-19肺炎患者4C死亡率评分和PRIEST COVID-19临床严重程度评分的外部验证

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-11-23 Print Date: 2022-12-01 DOI:10.2478/rjim-2022-0015
Themistoklis Paraskevas, Christos Michailides, Iosif Karalis, Anastasios Kantanis, Charikleia Chourpiliadi, Evgenia Matthaiakaki, Markos Marangos, Dimitrios Velissaris
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引用次数: 1

摘要

背景:预后评分可用于促进对患有危及生命疾病的患者进行更好的管理,前提是它们已在感兴趣的人群中进行了测试。目的:对4C死亡率评分和PRIEST COVID-19临床严重程度评分进行外部验证。研究设计:前瞻性观察性研究。方法:选取希腊某三级医院新冠肺炎住院患者为研究对象。根据入院资料计算预后评分,并进行ROC曲线分析。我们评估了院内死亡或需要有创通气的综合结果。结果:4C和PRIEST评分均表现出较好的判别能力,AUC值分别为0.826 (CI 95%: 0.765 ~ 0.887)和0.852 (CI 95%: 0.793 ~ 0.910)。基于约登指数,4C评分的最佳临界值为11(敏感性75%,特异性75.5%),而PRIEST评分的最佳临界值为10(敏感性83%,特异性69.4%)。除了PRIEST评分中的低风险组和非常高风险组外,两个评分的校准都是适当的。结论:4C死亡率评分和PRIEST COVID-19临床严重程度评分可用于希腊新冠肺炎住院人群预后不良患者的早期识别。
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External validation of the 4C Mortality Score and PRIEST COVID-19 Clinical Severity Score in patients hospitalized with COVID-19 pneumonia in Greece.

Background: Prognostic scores can be used to facilitate better management of patients suffering from life-threatening diseases, provided that they have been tested in the population of interest. Aim: To perform external validation of the 4C Mortality Score and PRIEST COVID-19 Clinical Severity Score. Study Design: Prospective observational Study. Methods: Patients hospitalized with COVID-19 pneumonia in a tertiary hospital in Greece were enrolled in the study. The prognostic scores were calculated based on hospital admission data and ROC curve analysis was performed. We assessed a composite outcome of either in-hospital death or need for invasive ventilation. Results: Both 4C and PRIEST scores showed good discriminative ability with an AUC value of 0.826 (CI 95%: 0.765-0.887) and 0.852 (CI 95%: 0.793-0.910) respectively. Based on the Youden Index the optimal cut-off for the 4C score was 11 (Sensitivity 75%, Specificity 75.5%) and 10 for the PRIEST score (Sensitivity 83% and Specificity 69.4%). Calibration was adequate for both scores, except for the low and very high risk groups in the PRIEST score. Conclusion: The 4C Mortality Score and PRIEST COVID-19 Clinical Severity Score can be used for early identification of patients with poor prognosis in a Greek population cohort hospitalized with COVID-19.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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