埃塞俄比亚幽门螺杆菌感染的诊断挑战:一项基于社区的横断面研究。

IF 2.7 4区 医学 Q2 Medicine Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-06-02 eCollection Date: 2022-01-01 DOI:10.1155/2022/4013020
Esayas Kebede Gudina, Hiwot Amare, Solomon Ali, Melkamu Berhane Arefayine, Dagmawi Tewolde, Million Tesfaye Eshete, Mulusew Gerbaba Jebena, Andreas Wieser, Guenter Froeschl, Markos Tesfaye, Hailemichael Desalegn, Mulatu Gashaw
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引用次数: 2

摘要

背景:在资源受限的国家,幽门螺杆菌感染的准确诊断仍然是一个挑战。本研究旨在评估埃塞俄比亚当地可用的血清学和粪便抗原检测试剂盒在管理疑似幽门螺杆菌感染患者中的临床应用。方法:以社区为基础的横断面研究对生活在埃塞俄比亚西南部的表面健康的成人和儿童进行了研究。对参与者进行了消化不良症状和相关临床状况的访谈。幽门螺杆菌感染检查使用市售血清学和粪便抗原试验。使用logistic回归模型分析幽门螺杆菌检测与消化不良症状之间的关系。结果:在最终分析的1392名参与者中,血清学和粪便抗原检测试剂盒分别检测出49.1%和6.5%的幽门螺杆菌感染阳性。在过去三个月内报告上腹症状的参与者(AOR = 1.93, 95% CI = 1.28-2.91)和最近接受消化不良治疗的参与者(AOR = 1.51, 95% CI = 1.05-2.18)血清学检测阳性的可能性较大。然而,在我们的研究中没有观察到消化不良症状与幽门螺杆菌粪便抗原阳性之间的联系。结论:在埃塞俄比亚,利用商业上可获得的诊断方法准确检测幽门螺杆菌感染仍然很困难。这些方法将难以保证幽门螺杆菌感染的充分诊断和早期治疗,以及合理使用抗生素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Diagnostic Challenges of Helicobacter pylori Infection in Ethiopia: A Community-Based Cross-Sectional Study.

Background: In resource-constrained countries, accurate diagnosis of Helicobacter pylori infection remains a challenge. This study aimed to assess the clinical utility of locally available serological and stool antigen test kits in the management of people with suspected H. pylori infection in Ethiopia.

Methods: A community-based cross-sectional study was conducted with apparently healthy adults and children living in southwest Ethiopia. Participants were interviewed for dyspepsia symptoms and related clinical conditions. H. pylori infection was examined using commercially available serological and stool antigen tests. The association between H. pylori tests and dyspepsia symptoms was analyzed using logistic regression models.

Results: Out of 1392 participants included in the final analysis, 49.1% and 6.5% tested positive for H. pylori infection with serology and stool antigen test kits, respectively. Participants reporting epigastric symptoms in the past three months (AOR = 1.93, 95% CI = 1.28-2.91) and those with recent dyspepsia treatment (AOR = 1.51, 95% CI = 1.05-2.18) were likely to have positive serology test. However, no association between dyspepsia symptoms and H. pylori stool antigen positivity was observed in our study.

Conclusion: ccurate detection of H. pylori infections using commercially accessible diagnostics remains difficult in Ethiopia. With these methods, it will be hard to ensure adequate diagnosis and early treatment of H. pylori infection, as well as rational antibiotic use.

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来源期刊
CiteScore
4.80
自引率
0.00%
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审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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