协调粪便微生物群移植:当前的技术进步和潜在的生物医学应用。

Frontiers in Medical Technology Pub Date : 2022-09-22 eCollection Date: 2022-01-01 DOI:10.3389/fmedt.2022.961569
Manisha Nigam, Abhaya Shikhar Panwar, Rahul Kunwar Singh
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引用次数: 5

摘要

粪便微生物群移植(FMT)已被证明是治疗微生物失衡引起的胃肠道疾病的有效方法。如今,这种方法被用于治疗胃肠道外疾病,如代谢和神经系统疾病,这些疾病被认为是肠道微生物生态失调的根源。尽管案例研究和临床试验已经证明了FMT在治疗各种疾病方面的潜力,但在这项技术被广泛应用于社区的整体利益之前,必须回答安全和伦理问题。从这个角度来看,改变肠道微生物群的技术可能代表一种潜力尚未得到彻底解决的药物形式,这并不意外。本综述旨在收集FMT的最新进展及其安全性、限制和伦理考虑的数据。
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Orchestrating the fecal microbiota transplantation: Current technological advancements and potential biomedical application.

Fecal microbiota transplantation (FMT) has been proved to be an effective treatment for gastrointestinal disorders caused due to microbial disbalance. Nowadays, this approach is being used to treat extragastrointestinal conditions like metabolic and neurological disorders, which are considered to have their provenance in microbial dysbiosis in the intestine. Even though case studies and clinical trials have demonstrated the potential of FMT in treating a variety of ailments, safety and ethical concerns must be answered before the technique is widely used to the community's overall benefit. From this perspective, it is not unexpected that techniques for altering gut microbiota may represent a form of medication whose potential has not yet been thoroughly addressed. This review intends to gather data on recent developments in FMT and its safety, constraints, and ethical considerations.

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