Editor's introduction to this issue (G&I 20:3, 2022).

miRNAs and genes, sig-nificantly involved in the etiology of early-stage OSCC. The authors identified a total of 23 differentially expressed miRNAs in patients with primary OSCC compared to the healthy controls, which targeted genes including CALM1, CYCS, THBS1, MYC, GATA6, SPRED3, PIK3R3, GIGYF1 , and BCL2L11 . The present study revealed a possible mech-anism mediating primary OSCC and may be useful for predicting the prognosis of patients with early-stage OSCC. Dr. presented a clinical, laboratory, and genetic study of a pathogenic variant of the CYP1B1 gene using whole-exome sequencing data from a rare case of primary congenital glaucoma. Dr. Rha (Yonsei University College of Medicine, Korea) and colleagues evaluated the frequencies of UGT1A polymorphisms and their relationship with clinicopathologic parameters in 382 Korean gastric cancer patients. Polymorphisms of UGT1A1*6, UGT1A1*27, UGT1A1*28, UGT1A1*60, UG-T1A7*2, UGT1A7*3 , and UGT1A9*22 were genotyped. While many clinically important findings were made, the most clinically important finding was about UGT1A9*22 . The genotype of UGT1A9*22 polymorphisms was shown to identify high-risk patients, among gastric cancer patients receiving irinotecan-containing chemotherapy and suffering severe