近年来,免疫学对牙周病有何影响?

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-10-16 DOI:10.1007/s00005-022-00662-9
Jan Kowalski, Maciej Nowak, Bartłomiej Górski, Renata Górska
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引用次数: 2

摘要

近几十年来,人们对牙周炎症的发病机制有了新的认识。传统的牙周病学侧重于生物膜控制、口腔卫生改善、专业的牙齿清洁和受损牙周组织的手术矫正,而新的破坏机制正在被提出。其中,最受关注的是宿主反应对该病临床表现的影响。大量的研究证明,从牙龈炎到牙周炎的转变不是疾病的简单进展,而是只发生在易感个体的事件。易感性可能源于促进生物膜积累和/或成熟的局部因素的出现,也可能源于全身特征,其中炎症反应的非特异性成分的过度反应和长时间搅动是至关重要的。本文综述了牙周病与免疫学之间的关系,并对近年来积累的知识进行了更新。在简要介绍了对牙周病病因的了解的进展后,介绍了研究最多和可能可行的牙周病免疫标志物。可能的新治疗策略,利用宿主反应-免疫调节和慢性氧化应激减少的性质的知识也提出。
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What Has Immunology Brought to Periodontal Disease in Recent Years?

Recent decades have shed a new light on the pathomechanism of periodontal inflammation. While classic periodontology concentrates on biofilm control, oral hygiene improvement, professional tooth cleaning and surgical correction of damaged periodontal tissues, new aspects of the destruction mechanisms are being raised. Among them, the greatest attention is paid to the influence of host response on the clinical manifestations of the disease. Numerous studies have proved that the shift from gingivitis to periodontitis is not a simple progress of the disease, but an event occurring only in susceptible individuals. Susceptibility may result from appearance of local factors facilitating biofilm accumulation and/or maturation, or from systemic features, among which over-reaction and prolonged agitation of non-specific component of inflammatory response is crucial. The present paper summarizes the association between periodontology and immunology and updates the knowledge accrued mostly in the recent years. After a brief explanation of advances in understanding of the disease aetiology, the most studied and potentially viable immunological markers of periodontal disease are presented. Possible new therapeutic strategies, exploiting knowledge about the nature of host response—immunomodulation and reduction of chronic oxidative stress—are also presented.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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