新型高分辨率PET系统的原型探测器:BazookaPET。

Ryeojin Park, Brian W Miller, Abhinav K Jha, Lars R Furenlid, William C J Hunter, Harrison H Barrett
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引用次数: 2

摘要

我们已经设计并正在开发一种名为BazookaPET的新型概念验证PET系统。为了完成PET配置,至少需要两个检测器元件来检测正电子湮灭事件。BazookaPET的每个检测器元素都有两个独立的数据采集通道。闪烁晶体的一侧光学耦合到4×4硅光电倍增管(SiPM)阵列,另一侧是基于ccd的伽马相机。利用这两个独立的通道,我们可以通过几个最大似然估计(MLE)步骤将数据输出关联起来,从而获得具有高能量、时间和空间分辨率的数据。在这项工作中,我们提出了系统的概念和原型探测器元件。我们专注于表征单个探测器通道,并显示了初步的实验校准结果以及初步的性能评估结果。我们测量了来自两个探测器通道输出的狭缝光束图像的能量分辨率和集成轨迹。在662 keV下,SiPM的光峰能量分辨率为~5.3%,CCD的光峰能量分辨率为~48%。我们假设SiPM信号遵循高斯统计量,并使用MLE估计二维相互作用位置。在标定实验的基础上,我们计算了SiPM探测器通道的cram - rao边界(CRB),发现CRB分辨率优于晶体中心1mm。
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A Prototype Detector for a Novel High-Resolution PET System: BazookaPET.

We have designed and are developing a novel proof-of-concept PET system called BazookaPET. In order to complete the PET configuration, at least two detector elements are required to detect positron-electron annihilation events. Each detector element of the BazookaPET has two independent data acquisition channels. One side of the scintillation crystal is optically coupled to a 4×4 silicon photomultiplier (SiPM) array and the other side is a CCD-based gamma camera. Using these two separate channels, we can obtain data with high energy, temporal and spatial resolution data by associating the data outputs via several maximum-likelihood estimation (MLE) steps. In this work, we present the concept of the system and the prototype detector element. We focus on characterizing individual detector channels, and initial experimental calibration results are shown along with preliminary performance-evaluation results. We measured energy resolution and the integrated traces of the slit-beam images from both detector channel outputs. A photo-peak energy resolution of ~5.3% FWHM was obtained from the SiPM and ~48% FWHM from the CCD at 662 keV. We assumed SiPM signals follow Gaussian statistics and estimated the 2D interaction position using MLE. Based on our the calibration experiments, we computed the Cramér-Rao bound (CRB) for the SiPM detector channel and found that the CRB resolution is better than 1 mm in the center of the crystal.

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