慢性髓性白血病成人患者达沙替尼诱发的股骨头血管性坏死

IF 3 Q2 Medicine Clinical Medicine Insights-Blood Disorders Pub Date : 2015-07-23 eCollection Date: 2015-01-01 DOI:10.4137/CMBD.S24628
Mohamed A Yassin, Abbas H Moustafa, Abdulqadir J Nashwan, Ashraf T Soliman, Hatim El Derhoubi, Shehab F Mohamed, Deena S Mudawi, Sarah ELkourashy, Deena-Raiza Asaari, Hope-Love G Gutierrez, Radwa M Hussein, Mohamed Al Musharraf, Samah Kohla, Ahmed Elsayed, Nader Al-Dewik
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引用次数: 0

摘要

慢性髓性白血病(CML)是一种骨髓增生性肿瘤,其特征是存在由t(9;22)(q34;q11)互变产生的费城(Ph)染色体。这种易位的分子结果是产生 BCR-ABL 融合基因,该基因编码一种组成型活性蛋白酪氨酸激酶。致癌蛋白酪氨酸激酶位于细胞质中,通过持续激活参与细胞周期、粘附和凋亡的多种信号通路,形成白血病表型。股骨头血管性坏死(AVNFH)不是一种特殊的疾病。它是由各种原因引起的并发症或继发性疾病。这些情况可能导致股骨头供血受损。股骨头缺血性坏死的诊断以临床表现为基础,并辅以特殊的放射学表现。我们报告了一例 34 岁的苏丹女性 CML 患者,她在接受达沙替尼二线治疗后出现了 AVNFH。虽然达沙替尼导致血管性坏死(AVN)的机制尚不明确,但可以推测是由于股骨头的微循环受阻所致。据我们所知,经过广泛的文献检索,这是首例由达沙替尼诱发的CML患者AVNFH的报道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Dasatinib Induced Avascular Necrosis of Femoral Head in Adult Patient with Chronic Myeloid Leukemia.

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia (Ph) chromosome resulting from the reciprocal translocation t(9;22)(q34;q11). The molecular consequence of this translocation is the generation of the BCR-ABL fusion gene, which encodes a constitutively active protein tyrosine kinase. The oncogenic protein tyrosine kinase, which is located in the cytoplasm, is responsible for the leukemia phenotype through the constitutive activation of multiple signaling pathways involved in the cell cycle and in adhesion and apoptosis. Avascular necrosis of the femoral head (AVNFH) is not a specific disease. It occurs as a complication or secondary to various causes. These conditions probably lead to impaired blood supply to the femoral head. The diagnosis of AVNFH is based on clinical findings and is supported by specific radiological manifestations. We reported a case of a 34-year-old Sudanese female with CML who developed AVNFH after receiving dasatinib as a second-line therapy. Though the mechanism by which dasatinib can cause avascular necrosis (AVN) is not clear, it can be postulated because of microcirculatory obstruction of the femoral head. To the best of our knowledge and after extensive literature search, this is the first reported case of AVNFH induced by dasatinib in a patient with CML.

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CiteScore
3.70
自引率
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审稿时长
8 weeks
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