绿唇贻贝:慢性健康状况的生物活性成分和治疗评价。

Samantha Coulson, Talia Palacios, Luis Vitetta
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引用次数: 10

摘要

绿唇贻贝(绿唇贻贝)仅在新西兰水域发现,并为世界各地的食品和营养保健工业种植和生产。传统上,小管藤被用作治疗人类和动物的各种关节痛的药物;然而,临床研究报告提供了相互矛盾的结果。许多体外研究已经报道了贻贝在各种条件下的抗炎活性,并且还证明了与药物(如非甾体抗炎药(NSAIDs))的协同作用,小管贝可以保护胃肠道粘膜衬里免受此类药物的侵害。据推测,小管假单胞菌的抗炎活性主要是由于脂质部分,然而,在贻贝肉中发现的主要化合物类别中,蛋白质和肽是最大的,分离物具有各种抗微生物、抗炎、抗氧化、生物粘附和抗高血压活性。本章概述了生物活性成分及其功能和治疗应用。此外,我们假设并提供支持性证据,表明胃肠道微生物群在类风湿性关节炎和骨关节炎等疾病过程中发挥重要作用,也在小管假单胞菌治疗慢性炎症的疗效中发挥重要作用。肠道微生物群的代谢能力可以改变生物活性食物成分,改变宿主对这些成分的暴露,潜在地增强或减弱它们对健康的影响。了解小管假单胞菌中生物活性化合物与共生菌和致病菌的相互作用,可能有助于开发新的干预措施来控制肠道和肠外炎症。
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Perna canaliculus (Green-Lipped Mussel): Bioactive Components and Therapeutic Evaluation for Chronic Health Conditions.

Perna canaliculus (Green-Lippped Mussel) is found only in New Zealand waters and is cultivated and manufactured for both the food and nutraceutical industry world-wide. P. canaliculus has traditionally been used as a therapeutic to treat various arthralgias in both humans and animals; however, clinical research reports provide conflicting results. Numerous in vitro studies have reported anti-inflammatory activity of the mussel under various conditions and also demonstrated a synergistic effect with pharmaceutical medications such as non-steroidal anti-inflammatory drugs (NSAIDs) with P. canaliculus protecting the gastrointestinal mucosal lining against such medications. It is proposed that the anti-inflammatory activity demonstrated by P. canaliculus is predominantly due to the lipid fraction, however, among the major classes of compounds found in mussel meat, proteins and peptides are the largest with isolates demonstrating various anti-microbial, anti-inflammatory, anti-oxidant, bioadhesive and anti-hypertensive activities. A review of the bioactive components, their function and therapeutic application is outlined in this chapter. Furthermore, we hypothesise and provide supportive evidence that the gastrointestinal microbiota play an important role in disease processes such as Rheumatoid arthritis and Osteoarthritis and also in the efficacy of P. canaliculus in chronic inflammatory conditions. The metabolic capacity of intestinal microbiota can modify bioactive food components altering the hosts' exposure to these components, potentially enhancing or diminishing their health effects. Understanding the interaction of the bioactive compounds in P. canaliculus with commensal and pathogenic bacteria may facilitate the development of novel interventions to control intestinal and extraintestinal inflammation.

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