平均血小板体积和脾肿大是埃及儿童家族性地中海热亚临床活性的有用标志物:一项横断面研究。

International Journal of Chronic Diseases Pub Date : 2015-01-01 Epub Date: 2015-07-13 DOI:10.1155/2015/152616
Huda Marzouk, Hala M Lotfy, Yomna Farag, L A Rashed, Kamal El-Garf
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引用次数: 6

摘要

目标。探讨平均血小板体积(MPV)和脾肿大是否可作为家族性地中海热(FMF)患儿无发作期的亚临床炎症指标。患者和方法。该研究包括97名患有FMF的儿童。MPV在4小时内按照标准实验室操作进行血样采集。腹腔超声(USG)检查脾肿大。结果。在我们研究的患者中,84.45%的患者检测到高MPV, FMF伴脾肿大患者的MPV明显高于无脾肿大患者。MPV与脾跨度有统计学意义(P = 0.045)。结论。FMF患儿无发作期MPV升高及其与脾跨度的显著相关性支持MPV和脾肿大作为FMF患者无发作期亚临床炎症的有用标志物。
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Mean Platelet Volume and Splenomegaly as Useful Markers of Subclinical Activity in Egyptian Children with Familial Mediterranean Fever: A Cross-Sectional Study.

Objective. To study whether mean platelet volume (MPV) and splenomegaly could be used as subclinical inflammatory markers in children with familial Mediterranean fever (FMF) at the attack-free period. Patients and Methods. The study included ninety-seven children with FMF. MPV was carried out within 4 hours of blood sampling according to standard laboratory practice. Splenomegaly was determined by abdominal ultrasound (USG). Results. High MPV was detected in 84.45% of our studied patients and was significantly higher in FMF patients with splenomegaly than in patients without splenomegaly. There was a statistically significant correlation between MPV and splenic span (P = 0.045). Conclusion. Elevated MPV and its significant correlation with splenic span in FMF children during the attack-free periods support the use of MPV and splenomegaly as useful markers of the subclinical inflammation in FMF patients at the attack-free period.

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