慢性肝病的评估:超声评分标准有帮助吗?

International Journal of Chronic Diseases Pub Date : 2013-01-01 Epub Date: 2013-09-10 DOI:10.1155/2013/326231
Shaista Afzal, Imrana Masroor, Madiha Beg
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引用次数: 19

摘要

评估肝脏组织学的无创方法包括常规实验室检查和放射学评估。本研究的目的是确定基于常规评估超声特征的简化评分系统在慢性肝病评估中的实用性,并将其与组织学结果联系起来。对于这个横断面分析研究,数据是通过非概率目的抽样技术前瞻性地收集的。评估超声变量/参数及其分配的评分系统,该评分系统采用已发表文献的修改版本。以分期和分级为参考标准,确定肝脏形态评分和肝脏形态及大小综合评分的敏感性、特异性、阳性预测值和阴性预测值。我们的研究结果表明,肝脏形态超声评估对CLD的分期和分级具有较高的敏感性和PPV,因此支持其作为筛查诊断策略。在三个肝脏形态学变量中,肝表面评价对纤维化分期和炎症分级的特异性最高。本研究评估的简化超声评分系统在区分CLD伴轻度或无纤维化、中度至重度纤维化患者方面具有临床相关性和可重复性。
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Evaluation of Chronic Liver Disease: Does Ultrasound Scoring Criteria Help?

Noninvasive approaches for assessment of liver histology include routine laboratory tests and radiological evaluation. The purpose of our study was to determine the utility of a simplified scoring system based on routinely evaluated ultrasound features for the evaluation of chronic liver disease and correlate it with the histological findings. For this cross-sectional analytical study the data was collected prospectively by nonprobability purposive sampling technique. The ultrasound variables/parameters and their assigned scoring system that was a modified version adopted from published literature were evaluated. Sensitivity, specificity, positive and negative predictive values of the liver morphological score and combined score of liver morphology and sizes was determined using stage and grade as reference standard. Our results show a high sensitivity and PPV of liver morphological sonographic evaluation for the staging and grading of CLD respectively thus supporting it as a screening diagnostic strategy. Of the three liver morphology variables, specificity of liver surface evaluation was highest for the stage of fibrosis and grade of inflammation. The simplified ultrasound scoring system evaluated in our study is clinically relevant and reproducible for differentiating patients with CLD with mild or no fibrosis from moderate to severe fibrosis.

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发文量
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审稿时长
7 weeks
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