{"title":"巨噬细胞在脑动静脉畸形发病机制中的作用。","authors":"Li Ma, Yi Guo, Yuan-Li Zhao, Hua Su","doi":"10.17554/j.issn.2409-3548.2015.01.12","DOIUrl":null,"url":null,"abstract":"<p><p>Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial hemorrhage, especially in children and young adults. Inflammation has been implicated in BAVM lesion progression. Among various inflammatory components, macrophage is one of the major inflammatory cells present in human ruptured and unruptured BAVM and in the BAVM lesions of animal models. The role of macrophage in BAVM pathogenesis is not fully understood. In this review, we summarize recent studies on macrophages and introduce a non-invasive imaging protocol as a potential tool for detecting macrophage in BAVM and predicting the risk of BAVM rupture.</p>","PeriodicalId":91093,"journal":{"name":"International journal of hematology research","volume":"1 2","pages":"52-56"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610371/pdf/nihms698657.pdf","citationCount":"9","resultStr":"{\"title\":\"The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.\",\"authors\":\"Li Ma, Yi Guo, Yuan-Li Zhao, Hua Su\",\"doi\":\"10.17554/j.issn.2409-3548.2015.01.12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial hemorrhage, especially in children and young adults. Inflammation has been implicated in BAVM lesion progression. Among various inflammatory components, macrophage is one of the major inflammatory cells present in human ruptured and unruptured BAVM and in the BAVM lesions of animal models. The role of macrophage in BAVM pathogenesis is not fully understood. In this review, we summarize recent studies on macrophages and introduce a non-invasive imaging protocol as a potential tool for detecting macrophage in BAVM and predicting the risk of BAVM rupture.</p>\",\"PeriodicalId\":91093,\"journal\":{\"name\":\"International journal of hematology research\",\"volume\":\"1 2\",\"pages\":\"52-56\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610371/pdf/nihms698657.pdf\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of hematology research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17554/j.issn.2409-3548.2015.01.12\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2015/7/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of hematology research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17554/j.issn.2409-3548.2015.01.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/7/6 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.
Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial hemorrhage, especially in children and young adults. Inflammation has been implicated in BAVM lesion progression. Among various inflammatory components, macrophage is one of the major inflammatory cells present in human ruptured and unruptured BAVM and in the BAVM lesions of animal models. The role of macrophage in BAVM pathogenesis is not fully understood. In this review, we summarize recent studies on macrophages and introduce a non-invasive imaging protocol as a potential tool for detecting macrophage in BAVM and predicting the risk of BAVM rupture.
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