绝经前和绝经后慢性丙型肝炎病毒(基因型4)感染患者女性性激素模式及其与疾病严重程度和治疗的关系

International Journal of Chronic Diseases Pub Date : 2015-01-01 Epub Date: 2015-08-17 DOI:10.1155/2015/927974
Nora H Ahmed, Taghrid B El-Abaseri, Hesham F El-Sayed, Taher I El-Serafi
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引用次数: 10

摘要

慢性丙型肝炎(CHC)病程在男性和女性之间存在差异。男性和绝经后妇女被认为是影响HCV感染进展的关键因素。本研究旨在评估女性性激素及其与HCV感染女性疾病严重程度和治疗的关系。研究对象分为2组:女性CHC患者44例,对照组44例。两组均分为绝经前和绝经后两组。采用化学发光免疫法测定血清雌二醇(E2)、孕酮(PRG)和总睾酮(TT)。我们的研究结果显示,绝经期患者的雌二醇、总睾酮和孕酮水平明显高于对照组(P < 0.001)。育龄期患者总睾酮水平低于绝经期患者(P < 0.001)。育龄期感染HCV的女性孕酮水平高于绝经期感染HCV的女性(P = 0.0014)。与育龄妇女相比,绝经妇女的疾病严重程度和治疗反应指标明显更差(纤维化:P < 0.001,活动:P = 0.045,治疗:P < 0.001)。我们观察到较低的雌二醇水平可能与CHC女性纤维化严重程度有关。仅在CHC绝经期女性中,较高的总睾酮和孕酮水平可能与纤维化严重程度和治疗反应差有关。
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Female Sex Hormones Pattern and Its Relation to Disease Severity and Treatment in Pre- and Postmenopausal Patients with Chronic Hepatitis C Virus (Genotype 4) Infection.

Chronic hepatitis C (CHC) course revealed differences between men and women. Male gender and postmenopausal women are thought to be of the critical factors affecting HCV infection progression. The study aimed to assess female sex hormones and their relation to disease severity and treatment in HCV infected females. Subjects were divided to 2 groups: 44 CHC female patients and 44 controls. Both groups were classified to premenopausal and postmenopausal females. Serum estradiol (E2), progesterone (PRG), and total testosterone (TT) were assessed using chemiluminescent immunoassay. Our results showed that menopausal patients had significantly higher levels of estradiol, total testosterone, and progesterone compared to controls (P < 0.001). Reproductive aged patients had lower level of total testosterone compared to menopausal patients (P < 0.001). HCV infected females of reproductive age had higher level of progesterone compared to menopausal HCV infected females (P = 0.0014). Indicators of disease severity and treatment response were significantly worse in menopausal women compared to reproductive aged women (fibrosis: P < 0.001, activity: P = 0.045, and treatment: P < 0.001). We observed that lower estradiol level may be related to fibrosis severity in CHC females. Higher total testosterone and progesterone levels may be related to fibrosis severity and poor response to treatment in CHC menopausal females only.

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