基于c6肽测定的一组欧洲有症状的猫的伯氏疏螺旋体血清阳性,并讨论了疾病病原学的意义。

IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Berliner und Munchener tierarztliche Wochenschrift Pub Date : 2016-07-01
Nikola Pantchev, Majda Globokar Vrhovec, Silvia Pluta, Reinhard K Straubinger
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引用次数: 0

摘要

关于猫莱姆病(LB)的报道很少。原因可能是猫与狗的蜱虫感染不同,对蜱虫感染的易感性较低,或者兽医对猫患者蜱虫疾病的认识较低。本研究的目的是测定猫血清中感应伯氏疏螺旋体抗体(Bbsl)的比例,比较猫与犬LB的意义,并评估可能对疾病发生的影响。采用酶免疫分析技术,快速检测猫体内Bbsl蛋白c6肽的特异性抗体。2009-2011年,德国和其他欧洲国家的兽医将血清样本送到诊断实验室,要求进行伯氏疏螺旋体血清学检测。兽医被要求提供有关猫的位置、年龄、性别、临床症状、治疗和随访的信息。271人中有6人(2.2%;95% CI: 0.8-4.8%)的猫血清中检测到针对Bbsl c6肽的抗体。在同一时期,猫血清中伯氏疏螺旋体抗体阳性的比例显著低于狗血清。所有阳性猫均生活在LB流行国家(德国、瑞典和比利时),除一只猫外,所有c6抗体阳性猫均出现临床症状。讨论了可能对疾病发生的影响。这里提供的数据表明,与居住在同一地区的狗相比,欧洲猫的伯氏疏螺旋体特异性c6抗体的患病率较低。97.8% (95% CI: 95.2-99.2%)的提交样本中缺乏针对Bbsl的抗体,这表明在猫中诊断为“猫LB”是罕见的。然而,在排除其他鉴别诊断的情况下,对于具有相容临床症状(例如,移动腿跛,在较小程度上是神经症状)的猫,应考虑LB。
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Seropositivity of Borrelia burgdorferi in a cohort of symptomatic cats from Europe based on a C6-peptide assay with discussion of implications in disease aetiology.

There are only few reports on Lyme borreliosis (LB) in cats. The reasons might be a different tick infestation in cats compared to dogs, a low susceptibility for tick-borne infections or a low awareness of veterinarians for tick-borne diseases in feline patients. The aim of this study was to determine the proportion of antibodies against Borrelia burgdorferi sensu lato (Bbsl) in feline sera, to compare the significance of feline versus canine LB, as well as to evaluate possible implications on disease occurrence. Specific antibodies against the C6-peptide of Bbsl in cats were detected by a rapid test based on enzyme immunoassay technique. The serum samples were sent to a diagnostic laboratory by veterinarians from Germany and other European countries with request for Borrelia serology in the years 2009-2011. Veterinarians were asked for information regarding the cats' location, age, gender, clinical signs, treatment and follow-up. In six of 271 (2.2%; 95% CI: 0.8-4.8%) cat sera, antibodies against the C6-peptide of Bbsl were detected. Proportion of Borrelia antibody-positive cat sera was significantly lower than the one determined for dogs during the same time period. All positive cats lived in countries endemic for LB (Germany, Sweden and Belgium), and all C6-antibody positive cats with the exception of one cat showed clinical signs. Possible implications on disease occurrence are discussed. Data presented here demonstrate a lower prevalence of Borrelia specific C6-antibodies in European cats when compared to dogs residing in the same regions. The absence of antibodies against Bbsl in 97.8% (95% CI: 95.2-99.2%) of the submitted samples indicate that diagnosis "feline LB"is rare in cats. Nevertheless, LB should be considered in cats with compatible clinical signs (e.g. shifting leg lameness, to less extent neurological signs) when other differential diagnoses are ruled out.

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来源期刊
CiteScore
0.90
自引率
0.00%
发文量
0
审稿时长
18-36 weeks
期刊介绍: The Berliner und Münchener Tierärztliche Wochenschrift is an open access, peer-reviewed journal that publishes contributions on all aspects of veterinary public health and its related subjects, such as epidemiology, bacteriology, virology, pathology, immunology, parasitology, and mycology. The journal publishes original research papers, review articles, case studies and short communications on farm animals, companion animals, equines, wild animals and laboratory animals. In addition, the editors regularly commission special issues on topics of major importance. The journal’s articles are published either in German or English and always include an abstract in the other language.
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