低水平维生素D与慢性稳定型心绞痛的关系:一项前瞻性病例对照研究。

Ab Hameed Raina, Mohammad Sultan Allai, Zafar Amin Shah, Khalid Hamid Changal, Manzoor Ahmad Raina, Fayaz Ahmad Bhat
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引用次数: 16

摘要

背景:在发达国家,冠状动脉疾病(CAD)是导致死亡和残疾的主要原因。慢性稳定型心绞痛是大约50%的冠心病患者的初始表现。最近的证据表明,维生素D对心血管健康至关重要。我们地区维生素D缺乏症的患病率为83%。低水平的维生素D与慢性稳定型心绞痛有关。目的:本研究旨在在我们的人群中支持或反驳这一假设。材料与方法:本研究为前瞻性病例对照研究。我们研究了100例慢性稳定型心绞痛,并将其与100例匹配的对照进行了比较。维生素D缺乏症定义为:结果:病例和对照组中维生素D缺乏症的患病率分别为75%和10%。结论:本研究提示维生素D缺乏与慢性稳定型心绞痛存在相关性。低水平可能是一个独立的、潜在的可改变的心血管危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Association of Low Levels of Vitamin D with Chronic Stable Angina: A Prospective Case-Control Study.

Background: Coronary artery disease (CAD) is a major cause of death and disability in developed countries. Chronic stable angina is the initial manifestation of CAD in approximately 50% of the patients. Recent evidence suggests that vitamin D is crucial for cardiovascular health. The prevalence of vitamin D deficiency in our region is 83%. A low level of vitamin D is associated with chronic stable angina.

Aim: This study was aimed at supporting or refuting this hypothesis in our population.

Materials and methods: The study was a prospective case-control study. We studied 100 cases of chronic stable angina and compared them with 100 matched controls. Vitamin D deficiency was defined as <20 ng/mL, vitamin D insufficiency as 20-30 ng/mL and normal vitamin D level as 31-150 ng/mL.

Results: The prevalence of vitamin D deficiency among cases and controls was 75% and 10%, respectively. 75% of the cases were vitamin D-deficient (<20 ng/mL); 12% were vitamin D-insufficient (20-30 ng/mL), and 13% had normal vitamin D levels (31-150 ng/mL). None had a toxic level of vitamin D. Among the controls, 10% were vitamin D-deficient, 33% were vitamin D-insufficient, and 57% had normal vitamin D levels. The mean vitamin level among cases and controls was 15.53 ng/mL and 40.95 ng/mL, respectively, with the difference being statistically significant (P ≤ 0.0001). There was no statistically significant relation between the disease severities, i.e., on coronary angiography (CAG) with vitamin D level. Among the cases, we found that an increasing age was inversely related to vitamin D levels (P = 0.027).

Conclusion: Our study indicates a correlation between vitamin D deficiency and chronic stable angina. Low levels may be an independent, potentially modifiable cardiovascular risk factor.

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